General Information of the Compound
Compound ID
CP0442603
Compound Name
6-(4-chlorophenyl)-3-(2-{[methyl(phenyl)amino]methyl}-6-quinolinyl)thieno[3,2-d]pyrimidin-4(3H)-one
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Structure
Formula
C29H21ClN4OS
Molecular Weight
509.034
Canonical SMILES
CN(Cc1ccc2cc(ccc2n1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1)c1ccccc1
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InChI
InChI=1S/C29H21ClN4OS/c1-33(23-5-3-2-4-6-23)17-22-12-9-20-15-24(13-14-25(20)32-22)34-18-31-26-16-27(36-28(26)29(34)35)19-7-10-21(30)11-8-19/h2-16,18H,17H2,1H3
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InChIKey
CUOBJGYPCXQATM-UHFFFAOYSA-N
Physicochemical Property
logP
6.9522
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
51.02
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11995241
SID: 17494358
ChEMBL ID
CHEMBL214891
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 87 nM
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