General Information of the Compound
Compound ID
CP0486158
Compound Name
1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-3-(2,6-dichloropyridin-4-yl)-1-(2-((2-fluoroethyl)(isopropyl)amino)ethyl)urea
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Structure
Formula
C27H32Cl2FN5O
Molecular Weight
532.491
Canonical SMILES
CC(C)N(CCF)CCN([C@@H]1CC[C@@]2(CC2C1)c1cccc(c1)C#N)C(=O)Nc1cc(Cl)nc(Cl)c1
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InChI
InChI=1S/C27H32Cl2FN5O/c1-18(2)34(9-8-30)10-11-35(26(36)32-22-14-24(28)33-25(29)15-22)23-6-7-27(16-21(27)13-23)20-5-3-4-19(12-20)17-31/h3-5,12,14-15,18,21,23H,6-11,13,16H2,1-2H3,(H,32,33,36)/t21?,23-,27-/m1/s1
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InChIKey
WBYMJQUHEGVCIO-OHUWNVLKSA-N
Physicochemical Property
logP
6.28428
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
72.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44424214
ChEMBL ID
CHEMBL229172
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 10 nM
   TI
   LI
   LO
   TS