General Information of the Compound
Compound ID
CP0545592
Compound Name
2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-2-(2-oxopyrrolidin-1-yl)acetamide
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Structure
Formula
C29H34F3N3O3
Molecular Weight
529.603
Canonical SMILES
CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCCC1=O)c1ccc(F)c(F)c1
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InChI
InChI=1S/C29H34F3N3O3/c1-2-34(28(37)27(35-14-3-5-26(35)36)20-7-9-24(31)25(32)17-20)13-4-12-33-15-10-29(11-16-33)23-18-22(30)8-6-21(23)19-38-29/h6-9,17-18,27H,2-5,10-16,19H2,1H3
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InChIKey
WDOXJJKADMHSEE-UHFFFAOYSA-N
Physicochemical Property
logP
4.5275
Rotatable Bonds
8
Heavy Atom Count
38
Polar Areas
53.09
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10459635
SID: 15481492
ChEMBL ID
CHEMBL564788
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.71 nM
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