General Information of the Compound
Compound ID
CP0432850
Compound Name
4-[[[[(3-chloro-4-fluorophenyl)amino]carbonyl][(trans-5-[4-(methylsulfonyl)phenyl]bicyclo[3.1.0]hex-2-yl]amino]methyl]-1-(methylsulfonyl)piperidine
    Show/Hide
Structure
Formula
C27H33ClFN3O5S2
Molecular Weight
598.162
Canonical SMILES
CS(=O)(=O)N1CCC(CN([C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)S(C)(=O)=O)C(=O)Nc2ccc(F)c(Cl)c2)CC1
    Show/Hide
InChI
InChI=1S/C27H33ClFN3O5S2/c1-38(34,35)21-6-3-19(4-7-21)27-12-9-25(22(27)16-27)32(17-18-10-13-31(14-11-18)39(2,36)37)26(33)30-20-5-8-24(29)23(28)15-20/h3-8,15,18,22,25H,9-14,16-17H2,1-2H3,(H,30,33)/t22-,25-,27-/m1/s1
    Show/Hide
InChIKey
FBXRGUMEPISGRA-AVPJRLCVSA-N
Physicochemical Property
logP
4.5084
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
103.86
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44409689
ChEMBL ID
CHEMBL206825
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 974 nM
   TI
   LI
   LO
   TS