General Information of the Compound
Compound ID
CP0434056
Compound Name
4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-(pyrrolidine-1-carbonyl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
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Structure
Formula
C33H29F4N5O
Molecular Weight
587.621
Canonical SMILES
Fc1cc2[nH]c(nc2cc1C(F)(F)F)C1(CC11CCN(CC1)C(=O)N1CCCC1)c1ccc(cc1)-c1cccc(c1)C#N
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InChI
InChI=1S/C33H29F4N5O/c34-26-18-28-27(17-25(26)33(35,36)37)39-29(40-28)32(24-8-6-22(7-9-24)23-5-3-4-21(16-23)19-38)20-31(32)10-14-42(15-11-31)30(43)41-12-1-2-13-41/h3-9,16-18H,1-2,10-15,20H2,(H,39,40)
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InChIKey
RTXJBKDZSRSMLJ-UHFFFAOYSA-N
Physicochemical Property
logP
7.24728
Rotatable Bonds
3
Heavy Atom Count
43
Polar Areas
76.02
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11527169
SID: 16629075
ChEMBL ID
CHEMBL208635
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 44 nM
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