General Information of the Compound
Compound ID
CP0396718
Compound Name
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-methylphenyl)benzamide
    Show/Hide
Structure
Formula
C27H30N2O
Molecular Weight
398.55
Canonical SMILES
CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(C)cc3)ccc2C1
    Show/Hide
InChI
InChI=1S/C27H30N2O/c1-19-4-7-21(8-5-19)22-10-12-23(13-11-22)27(30)28-26-15-14-24-16-20(18-29(2)3)6-9-25(24)17-26/h4-5,7-8,10-15,17,20H,6,9,16,18H2,1-3H3,(H,28,30)
    Show/Hide
InChIKey
LZYYQXOPZXIZAG-UHFFFAOYSA-N
Physicochemical Property
logP
5.58082
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 23593474
ChEMBL ID
CHEMBL1818784
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 8.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 18 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS