General Information of the Compound
Compound ID
CP0496561
Compound Name
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-methylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(4-methylpiperazin-1-yl)propyl]urea
    Show/Hide
Structure
Formula
C28H36ClFN4O
Molecular Weight
499.074
Canonical SMILES
CN1CCN(CCCN([C@@H]2CC[C@@]3(C[C@H]23)c2cccc(C)c2)C(=O)Nc2ccc(F)c(Cl)c2)CC1
    Show/Hide
InChI
InChI=1S/C28H36ClFN4O/c1-20-5-3-6-21(17-20)28-10-9-26(23(28)19-28)34(12-4-11-33-15-13-32(2)14-16-33)27(35)31-22-7-8-25(30)24(29)18-22/h3,5-8,17-18,23,26H,4,9-16,19H2,1-2H3,(H,31,35)/t23-,26-,28-/m1/s1
    Show/Hide
InChIKey
XXDNNAGREZBRMJ-KODFZCBSSA-N
Physicochemical Property
logP
5.37922
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
38.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 11698964
SID: 16803474
ChEMBL ID
CHEMBL205874
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 33 nM
   TI
   LI
   LO
   TS