General Information of the Compound
Compound ID
CP0429041
Compound Name
6-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-2-phenylsulfanyl-5H-pyrrolo[3,4-b]pyridin-7-one
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Synonyms
PMID25522065-Compound-29
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Structure
Formula
C26H27N3O3S
Molecular Weight
461.587
Canonical SMILES
COc1cc(ccc1OCCN1CCCC1)N1Cc2ccc(Sc3ccccc3)nc2C1=O
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InChI
InChI=1S/C26H27N3O3S/c1-31-23-17-20(10-11-22(23)32-16-15-28-13-5-6-14-28)29-18-19-9-12-24(27-25(19)26(29)30)33-21-7-3-2-4-8-21/h2-4,7-12,17H,5-6,13-16,18H2,1H3
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InChIKey
PULOMQYOCPKDEH-UHFFFAOYSA-N
Physicochemical Property
logP
4.8764
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
54.9
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 60169095
SID: 144118275
ChEMBL ID
CHEMBL2337724
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( PMID25522065-Compound-29 )
Drug Name PMID25522065-Compound-29
Target(s)
Melanin-concentrating hormone receptor 1 (MCHR1)
Antagonist