General Information of the Compound
Compound ID
CP0394860
Compound Name
1-(2-acetyl-1,3,4,5-tetrahydro-2-benzazepin-8-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
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Structure
Formula
C27H33ClN2O2
Molecular Weight
453.026
Canonical SMILES
CC(=O)N1CCCc2ccc(cc2C1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1
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InChI
InChI=1S/C27H33ClN2O2/c1-20(31)30-15-2-4-21-6-7-24(18-25(21)19-30)27(32)5-3-14-29-16-12-23(13-17-29)22-8-10-26(28)11-9-22/h6-11,18,23H,2-5,12-17,19H2,1H3
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InChIKey
YTFZTIDQFURVGW-UHFFFAOYSA-N
Physicochemical Property
logP
5.4772
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
40.62
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57391045
ChEMBL ID
CHEMBL1914851
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 86 nM
   TI
   LI
   LO
   TS