General Information of the Compound
Compound ID
CP0526231
Compound Name
3-(3-chloro-4-fluorophenyl)-1-(2-(diisopropylamino)ethyl)-1-((3R,6S)-6-(3-(methylsulfonamidomethyl)phenyl)bicyclo[4.1.0]heptan-3-yl)urea
    Show/Hide
Structure
Formula
C30H42ClFN4O3S
Molecular Weight
593.209
Canonical SMILES
CC(C)N(CCN([C@@H]1CC[C@@]2(CC2C1)c1cccc(CNS(C)(=O)=O)c1)C(=O)Nc1ccc(F)c(Cl)c1)C(C)C
    Show/Hide
InChI
InChI=1S/C30H42ClFN4O3S/c1-20(2)35(21(3)4)13-14-36(29(37)34-25-9-10-28(32)27(31)17-25)26-11-12-30(18-24(30)16-26)23-8-6-7-22(15-23)19-33-40(5,38)39/h6-10,15,17,20-21,24,26,33H,11-14,16,18-19H2,1-5H3,(H,34,37)/t24?,26-,30-/m1/s1
    Show/Hide
InChIKey
HSSCXHCWSGPAFF-JVIIYPEASA-N
Physicochemical Property
logP
5.9914
Rotatable Bonds
11
Heavy Atom Count
40
Polar Areas
81.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44424246
ChEMBL ID
CHEMBL375465
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 18 nM
   TI
   LI
   LO
   TS