General Information of the Compound
Compound ID
CP0514385
Compound Name
3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(4-methylsulfonylphenyl)-2-bicyclo[3.1.0]hexanyl]-1-[3-(2-oxopyrrolidin-1-yl)propyl]urea
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Structure
Formula
C27H31ClFN3O4S
Molecular Weight
548.08
Canonical SMILES
CS(=O)(=O)c1ccc(cc1)[C@@]12C[C@@H]1[C@@H](CC2)N(CCCN1CCCC1=O)C(=O)Nc1ccc(F)c(Cl)c1
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InChI
InChI=1S/C27H31ClFN3O4S/c1-37(35,36)20-8-5-18(6-9-20)27-12-11-24(21(27)17-27)32(15-3-14-31-13-2-4-25(31)33)26(34)30-19-7-10-23(29)22(28)16-19/h5-10,16,21,24H,2-4,11-15,17H2,1H3,(H,30,34)/t21-,24-,27-/m1/s1
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InChIKey
CJVGLJJODOOTRM-GNMGOMLTSA-N
Physicochemical Property
logP
4.8493
Rotatable Bonds
8
Heavy Atom Count
37
Polar Areas
86.79
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11541231
SID: 16643303
ChEMBL ID
CHEMBL382772
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1615 nM
   TI
   LI
   LO
   TS