General Information of the Compound
Compound ID
CP0506243
Compound Name
4-[3-(2-Bromo-4-trifluoromethoxy-phenyl)-ureido]-N-(2-diethylamino-ethyl)-2-methoxy-benzamide
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Structure
Formula
C22H26BrF3N4O4
Molecular Weight
547.372
Canonical SMILES
CCN(CC)CCNC(=O)c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2Br)cc1OC
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InChI
InChI=1S/C22H26BrF3N4O4/c1-4-30(5-2)11-10-27-20(31)16-8-6-14(12-19(16)33-3)28-21(32)29-18-9-7-15(13-17(18)23)34-22(24,25)26/h6-9,12-13H,4-5,10-11H2,1-3H3,(H,27,31)(H2,28,29,32)
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InChIKey
RHZBJESXJUHVTP-UHFFFAOYSA-N
Physicochemical Property
logP
5.0719
Rotatable Bonds
10
Heavy Atom Count
34
Polar Areas
91.93
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44395082
ChEMBL ID
CHEMBL183839
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 8800 nM
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