General Information of the Compound
Compound ID
CP0466559
Compound Name
4-[4-[[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]carbamoyl]phenyl]benzoic acid
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Structure
Formula
C27H28N2O3
Molecular Weight
428.532
Canonical SMILES
CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(O)=O)ccc2C1
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InChI
InChI=1S/C27H28N2O3/c1-29(2)17-18-3-4-24-16-25(14-13-23(24)15-18)28-26(30)21-9-5-19(6-10-21)20-7-11-22(12-8-20)27(31)32/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30)(H,31,32)
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InChIKey
XZVWWFWTYRYEDX-UHFFFAOYSA-N
Physicochemical Property
logP
4.9706
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
69.64
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 21939881
ChEMBL ID
CHEMBL1818789
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 230 nM
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