General Information of the Compound
Compound ID
CP0421008
Compound Name
5-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pentanamide
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Structure
Formula
C26H30FN3O
Molecular Weight
419.544
Canonical SMILES
Cc1c(NC(=O)CCCCc2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12
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InChI
InChI=1S/C26H30FN3O/c1-19-24(29-25(31)7-3-2-6-20-8-11-23(27)12-9-20)13-10-22-16-21(17-28-26(19)22)18-30-14-4-5-15-30/h8-13,16-17H,2-7,14-15,18H2,1H3,(H,29,31)
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InChIKey
USBRYOLVHLYFPX-UHFFFAOYSA-N
Physicochemical Property
logP
5.62962
Rotatable Bonds
8
Heavy Atom Count
31
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18436119
SID: 137280402
ChEMBL ID
CHEMBL2059416
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01027, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
Protein ID: PT01388, Melanin-concentrating hormone receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS