| Compound ID |
Compound Name |
Compound Formula |
|
CP0451036
|
methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5S)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-triethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C52H73N7O8Si
|
2
|
| 1 |
EC50 = 0.01 nM
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|
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| 2 |
EC50 = 0.445 nM
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|
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CP0644004
|
VELPATASVIR
Show/Hide
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C49H54N8O8
|
16
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| 1 |
EC50 = 0.01 nM
|
|
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| 2 |
EC50 = 0.011 nM
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|
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| 3 |
EC50 = 0.013 nM
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|
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| 4 |
EC50 = 0.014 nM
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|
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| 5 |
EC50 = 0.016 nM
|
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| 6 |
EC50 = 0.031 nM
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|
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| 7 |
EC50 = 0.032 nM
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| 8 |
EC50 = 0.053 nM
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| 9 |
EC50 = 0.054 nM
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|
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| 10 |
EC50 = 0.105 nM
|
|
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| 11 |
EC50 = 0.13 nM
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|
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| 12 |
EC50 = 0.21 nM
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|
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| 13 |
EC50 = 0.22 nM
|
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| 14 |
EC50 = 0.25 nM
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| 15 |
EC50 = 3.2 nM
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| 16 |
EC50 = 8.5 nM
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CP0931256
|
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(1S,3S,5R)-2-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2-azabicyclo[3.1.0]hexan-3-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C49H52N8O8
|
4
|
| 1 |
EC50 = 0.01 nM
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|
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| 2 |
EC50 = 0.011 nM
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|
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| 3 |
EC50 = 0.046 nM
|
|
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| 4 |
EC50 = 0.113 nM
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CP0941214
|
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(dibenzo[a,c]phenazine-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
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|
C48H52N10O6
|
3
|
| 1 |
EC50 = 0.01 nM
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|
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| 2 |
EC50 = 1.47 nM
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| 3 |
EC50 = 5.99 nM
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CP0931255
|
methyl N-[(2S)-1-[(2S)-2-[5-[13-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C42H50N8O9
|
4
|
| 1 |
EC50 = 0.01 nM
|
|
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| 2 |
EC50 = 0.079 nM
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| 3 |
EC50 = 0.087 nM
|
|
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| 4 |
EC50 = 3.67 nM
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CP0912264
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methyl N-[(2S)-1-[(2S,4S)-2-[17-[2-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C47H58N8O9
|
5
|
| 1 |
EC50 = 0.01 nM
|
|
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| 2 |
EC50 = 0.024 nM
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|
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| 3 |
EC50 = 0.034 nM
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| 4 |
EC50 = 0.061 nM
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|
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| 5 |
EC50 = 0.18 nM
|
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CP0869642
|
Ravidasvir
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|
C42H51N9O6
|
3
|
| 1 |
EC50 = 0.01 nM
|
|
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| 2 |
EC50 = 0.12 nM
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|
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| 3 |
EC50 = 1.14 nM
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CP0402786
|
methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5S)-1-[4-[tert-butyl(dimethyl)silyl]phenyl]-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C52H73N7O8Si
|
3
|
| 1 |
EC50 = 0.011 nM
|
|
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| 2 |
EC50 = 0.012 nM
|
|
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| 3 |
EC50 = 0.925 nM
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CP0912260
|
methyl N-[(2S)-1-[(2S)-2-[5-[6-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C44H52N8O7
|
6
|
| 1 |
EC50 = 0.011 nM
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|
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| 2 |
EC50 = 0.018 nM
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| 3 |
EC50 = 0.019 nM
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|
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| 4 |
EC50 = 0.02 nM
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| 5 |
EC50 = 0.077 nM
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| 6 |
EC50 = 0.234 nM
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CP0931254
|
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C48H52N8O8
|
3
|
| 1 |
EC50 = 0.011 nM
|
|
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| 2 |
EC50 = 0.013 nM
|
|
|
| 3 |
EC50 = 0.019 nM
|
|
|
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CP0941215
|
methyl N-[(2S)-1-[(2S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C44H52N8O7
|
4
|
| 1 |
EC50 = 0.011 nM
|
|
|
| 2 |
EC50 = 0.018 nM
|
|
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| 3 |
EC50 = 0.132 nM
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|
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| 4 |
EC50 = 0.443 nM
|
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|
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CP0948415
|
methyl N-[(2S)-1-[(2S,5S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-(methoxymethyl)pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C46H56N8O8
|
5
|
| 1 |
EC50 = 0.011 nM
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|
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| 2 |
EC50 = 0.012 nM
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|
|
| 3 |
EC50 = 0.017 nM
|
|
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| 4 |
EC50 = 0.067 nM
|
|
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| 5 |
EC50 = 0.157 nM
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|
CP0949895
|
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C49H54N8O8
|
5
|
| 1 |
EC50 = 0.011 nM
|
|
|
| 2 |
EC50 = 0.013 nM
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|
|
| 3 |
EC50 = 0.014 nM
|
|
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| 4 |
EC50 = 0.015 nM
|
|
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| 5 |
EC50 = 0.017 nM
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CP0547986
|
N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(pyridine-4-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-4-carboxamide
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|
C54H46N8O4S2
|
1
|
| 1 |
EC50 = 0.011 nM
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|
|
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CP0904044
|
methyl N-[(R)-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-phenyl-methyl]carbamate
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|
C45H49N9O6
|
3
|
| 1 |
EC50 = 0.011 nM
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|
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| 2 |
EC50 = 0.06 nM
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|
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| 3 |
EC50 = 0.11 nM
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CP0931253
|
methyl N-[(2S)-1-[(2S,5S)-2-[17-[2-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C45H54N8O7
|
4
|
| 1 |
EC50 = 0.012 nM
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|
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| 2 |
EC50 = 0.014 nM
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| 3 |
EC50 = 0.063 nM
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|
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| 4 |
EC50 = 0.28 nM
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CP0865367
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methyl N-[(1R)-2-[(2S)-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C46H48N8O7
|
4
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| 1 |
EC50 = 0.012 nM
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| 2 |
EC50 = 0.021 nM
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| 3 |
EC50 = 0.022 nM
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| 4 |
EC50 = 0.134 nM
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CP0948414
|
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(1R,3S,5S)-2-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2-azabicyclo[3.1.0]hexan-3-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C49H52N8O8
|
4
|
| 1 |
EC50 = 0.013 nM
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| 2 |
EC50 = 0.02 nM
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| 3 |
EC50 = 0.021 nM
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|
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| 4 |
EC50 = 0.028 nM
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CP0865364
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methyl N-[(1R)-2-[(2S,4S)-2-[5-[13-[2-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C48H54N8O9
|
7
|
| 1 |
EC50 = 0.013 nM
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|
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| 2 |
EC50 = 0.016 nM
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|
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| 3 |
EC50 = 0.022 nM
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| 4 |
EC50 = 0.081 nM
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| 5 |
EC50 = 0.11 nM
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| 6 |
EC50 = 0.29 nM
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| 7 |
EC50 = 0.48 nM
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CP0947115
|
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(4-oxo-4H-cyclopenta[def]phenanthrene-2,6-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
|
C43H48N8O7
|
3
|
| 1 |
EC50 = 0.013 nM
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| 2 |
EC50 = 0.073 nM
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| 3 |
EC50 = 0.22 nM
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CP0556566
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(butanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]butanamide
Show/Hide
|
C50H52N6O4S2
|
1
|
| 1 |
EC50 = 0.013 nM
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CP0451035
|
methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5S)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-trimethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C49H67N7O8Si
|
3
|
| 1 |
EC50 = 0.014 nM
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|
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| 2 |
EC50 = 0.038 nM
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| 3 |
EC50 = 1.411 nM
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CP0949893
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methyl N-[(2S)-1-[(2S,4S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-(methoxymethyl)pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C46H56N8O8
|
4
|
| 1 |
EC50 = 0.014 nM
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| 2 |
EC50 = 0.019 nM
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| 3 |
EC50 = 0.106 nM
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| 4 |
EC50 = 0.166 nM
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CP0865372
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methyl N-[(1S)-2-[(2S)-2-[5-[13-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-1-(oxan-4-yl)-2-oxoethyl]carbamate
Show/Hide
|
C44H52N8O9
|
5
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| 1 |
EC50 = 0.014 nM
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| 2 |
EC50 = 0.172 nM
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| 3 |
EC50 = 0.185 nM
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| 4 |
EC50 = 1.33 nM
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| 5 |
EC50 = 1.43 nM
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CP0948416
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(5H-naphtho[8,1,2-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
|
C43H50N8O7
|
5
|
| 1 |
EC50 = 0.014 nM
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| 2 |
EC50 = 0.022 nM
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| 3 |
EC50 = 0.063 nM
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| 4 |
EC50 = 10.2 nM
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| 5 |
EC50 = 19.7 nM
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CP0869647
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methyl N-[(1R)-2-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S)-1-(methoxycarbonylamino)-2-methyl-propyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamate
Show/Hide
|
C45H49N9O6
|
3
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| 1 |
EC50 = 0.014 nM
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| 2 |
EC50 = 0.03 nM
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| 3 |
EC50 = 0.22 nM
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CP0930993
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MethylN-[(1R)-2-[(2S)-2-{5-[4-(4-{2-[(2S)-1-[(2R)-2-[(Methoxycarbonyl)amino]-2-phenylacetyl]pyrrolidin-2-yl]-1H-1Himidazol-5-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C46H46N8O6
|
2
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| 1 |
EC50 = 0.014 nM
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| 2 |
EC50 = 0.098 nM
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CP0912261
|
methyl N-[(2S)-1-[(2S,4S)-4-ethoxy-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C45H54N8O8
|
4
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| 1 |
EC50 = 0.015 nM
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| 2 |
EC50 = 0.018 nM
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| 3 |
EC50 = 0.265 nM
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| 4 |
EC50 = 0.378 nM
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CP0865363
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methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-methylpyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C48H52N8O7
|
2
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| 1 |
EC50 = 0.015 nM
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| 2 |
EC50 = 0.053 nM
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CP0869648
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methyl N-[(1S,2S)-1-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S,2S)-1-(methoxycarbonylamino)-2-methyl-butyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-butyl]carbamate
Show/Hide
|
C44H55N9O6
|
3
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| 1 |
EC50 = 0.015 nM
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| 2 |
EC50 = 0.11 nM
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| 3 |
EC50 = 2.3 nM
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CP0907326
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methyl N-[(1S,2S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-butyl]carbamate
Show/Hide
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C43H53N9O7
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3
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| 1 |
EC50 = 0.015 nM
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| 2 |
EC50 = 0.07 nM
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| 3 |
EC50 = 1.03 nM
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CP0865362
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methyl N-[(2S)-1-[(2S)-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
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C43H50N8O7
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4
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| 1 |
EC50 = 0.016 nM
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| 2 |
EC50 = 0.017 nM
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| 3 |
EC50 = 0.162 nM
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| 4 |
EC50 = 1.16 nM
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CP0865360
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
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C42H50N8O8
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8
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| 1 |
EC50 = 0.016 nM
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| 2 |
EC50 = 0.022 nM
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| 3 |
EC50 = 0.029 nM
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| 4 |
EC50 = 0.056 nM
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| 5 |
EC50 = 1.16 nM
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| 6 |
EC50 = 1.77 nM
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| 7 |
EC50 = 5.9 nM
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| 8 |
EC50 = 8.81 nM
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CP0865368
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methyl N-[(1R)-2-[(2S)-2-[5-[6-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
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C46H48N8O7
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4
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| 1 |
EC50 = 0.016 nM
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| 2 |
EC50 = 0.033 nM
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| 3 |
EC50 = 0.035 nM
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| 4 |
EC50 = 0.073 nM
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CP0865375
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methyl N-[(2S)-1-[(2S)-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-6,8-diazapentacyclo[11.8.0.02,10.05,9.014,19]henicosa-1(13),2(10),3,5(9),7,11,14(19),15,17-nonaen-7-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
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C43H50N8O7
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5
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| 1 |
EC50 = 0.016 nM
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| 2 |
EC50 = 0.017 nM
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| 3 |
EC50 = 0.041 nM
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| 4 |
EC50 = 20.9 nM
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| 5 |
EC50 = 32.3 nM
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CP0950579
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(9,10-dihydro-5H-naphtho[8,1,2-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
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C43H52N8O7
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4
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| 1 |
EC50 = 0.016 nM
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| 2 |
EC50 = 0.028 nM
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| 3 |
EC50 = 0.065 nM
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| 4 |
EC50 = 23.7 nM
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CP0535194
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(propanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]propanamide
Show/Hide
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C48H48N6O4S2
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1
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| 1 |
EC50 = 0.016 nM
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CP0575371
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(piperidine-1-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]piperidine-1-carboxamide
Show/Hide
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C54H58N8O4S2
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1
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| 1 |
EC50 = 0.016 nM
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CP0575370
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(3-pyrrol-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-pyrrol-1-ylpropanamide
Show/Hide
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C56H54N8O4S2
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1
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| 1 |
EC50 = 0.017 nM
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CP0867642
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(dibenzo[f,h]quinoxaline-6,11-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
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C44H50N10O6
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3
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| 1 |
EC50 = 0.018 nM
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| 2 |
EC50 = 0.223 nM
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| 3 |
EC50 = 0.528 nM
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CP0865369
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methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-methylpyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
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C48H52N8O7
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6
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| 1 |
EC50 = 0.018 nM
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| 2 |
EC50 = 0.027 nM
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| 3 |
EC50 = 0.03 nM
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| 4 |
EC50 = 0.033 nM
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| 5 |
EC50 = 0.045 nM
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| 6 |
EC50 = 0.063 nM
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CP0867439
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benzyl N-[(3R)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-[(4-methoxypiperidine-1-carbonyl)amino]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]pyrrolidin-3-yl]carbamate
Show/Hide
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C47H52N8O6
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3
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| 1 |
EC50 = 0.018 nM
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| 2 |
EC50 = 0.028 nM
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| 3 |
EC50 = 0.039 nM
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CP0865374
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dimethyl (2S,2'S,3S,3'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxopentane-2,1-diyl)dicarbamate
Show/Hide
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C44H54N8O8
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4
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| 1 |
EC50 = 0.019 nM
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| 2 |
EC50 = 0.031 nM
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| 3 |
EC50 = 1.85 nM
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| 4 |
EC50 = 12.1 nM
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CP0865371
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(5,9-dihydroisochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
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C42H50N8O8
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4
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| 1 |
EC50 = 0.019 nM
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| 2 |
EC50 = 0.021 nM
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| 3 |
EC50 = 0.087 nM
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| 4 |
EC50 = 9.85 nM
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CP0962190
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methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(3R)-4-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]morpholin-3-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
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C42H51N9O7
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2
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| 1 |
EC50 = 0.019 nM
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| 2 |
EC50 = 0.66 nM
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CP0865376
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dimethyl (1R,1'R)-2,2'-((2S,2'S,5S,5'S)-5,5'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(2-methylpyrrolidine-5,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl)dicarbamate
Show/Hide
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C50H50N8O8
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4
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| 1 |
EC50 = 0.02 nM
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| 2 |
EC50 = 0.094 nM
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| 3 |
EC50 = 0.15 nM
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| 4 |
EC50 = 1.835 nM
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CP0947114
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dimethyl (1R,1'R)-2,2'-((3S,3'S,5S,5'S)-5,5'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(3-methylpyrrolidine-5,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl)dicarbamate
Show/Hide
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C50H50N8O8
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4
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| 1 |
EC50 = 0.02 nM
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| 2 |
EC50 = 0.026 nM
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| 3 |
EC50 = 0.031 nM
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| 4 |
EC50 = 0.058 nM
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CP0951334
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dimethyl (1S,1'S)-2,2'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(1-cyclobutyl-2-oxoethane-2,1-diyl)dicarbamate
Show/Hide
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C44H50N8O8
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3
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| 1 |
EC50 = 0.02 nM
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| 2 |
EC50 = 0.053 nM
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| 3 |
EC50 = 31.3 nM
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CP0865365
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dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(triphenylene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
Show/Hide
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C46H52N8O6
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3
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| 1 |
EC50 = 0.02 nM
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| 2 |
EC50 = 0.092 nM
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| 3 |
EC50 = 6.79 nM
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CP0434257
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-acetamido-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]acetamide
Show/Hide
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C46H44N6O4S2
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1
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| 1 |
EC50 = 0.02 nM
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CP0562017
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(morpholine-4-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]morpholine-4-carboxamide
Show/Hide
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C52H54N8O6S2
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1
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| 1 |
EC50 = 0.02 nM
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CP0868992
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benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-[(4-methoxypiperidine-1-carbonyl)amino]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
Show/Hide
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C46H51N7O6
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2
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| 1 |
EC50 = 0.02 nM
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| 2 |
EC50 = 2.3 nM
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CP0865370
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methyl N-[(2S)-1-[(2S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-(methoxymethyl)pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C45H54N8O8
|
12
|
| 1 |
EC50 = 0.021 nM
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| 2 |
EC50 = 0.026 nM
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| 3 |
EC50 = 0.037 nM
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| 4 |
EC50 = 0.086 nM
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| 5 |
EC50 = 0.135 nM
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| 6 |
EC50 = 0.15 nM
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| 7 |
EC50 = 0.19 nM
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| 8 |
EC50 = 0.22 nM
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| 9 |
EC50 = 0.28 nM
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| 10 |
EC50 = 0.37 nM
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| 11 |
EC50 = 4.7 nM
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| 12 |
EC50 = 10.4 nM
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CP0865366
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methyl N-[(1S)-1-[(2S)-2-[5-[7-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-4,5,9,10-tetrahydropyren-2-yl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate
Show/Hide
|
C44H54N8O6
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4
|
| 1 |
EC50 = 0.021 nM
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| 2 |
EC50 = 0.131 nM
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| 3 |
EC50 = 0.156 nM
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| 4 |
EC50 = 13.3 nM
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CP0907328
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methyl N-[(1S)-1-[[(3R)-3-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]morpholine-4-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C42H51N9O7
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2
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| 1 |
EC50 = 0.021 nM
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| 2 |
EC50 = 0.4 nM
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CP0865361
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dimethyl (1S,1'S)-2,2'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(1-cyclopentyl-2-oxoethane-2,1-diyl)dicarbamate
Show/Hide
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C46H54N8O8
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3
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| 1 |
EC50 = 0.022 nM
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| 2 |
EC50 = 0.055 nM
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| 3 |
EC50 > 44 nM
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CP0867643
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dimethyl (1R,1'R)-2,2'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl)dicarbamate
Show/Hide
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C48H46N8O8
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5
|
| 1 |
EC50 = 0.022 nM
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| 2 |
EC50 = 0.048 nM
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| 3 |
EC50 = 0.093 nM
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| 4 |
EC50 = 0.145 nM
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| 5 |
EC50 = 0.24 nM
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CP0865373
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methyl N-[(1R)-2-[(2S)-2-[5-[13-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-2-(oxan-4-yl)acetyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C47H50N8O9
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5
|
| 1 |
EC50 = 0.022 nM
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| 2 |
EC50 = 0.057 nM
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| 3 |
EC50 = 0.28 nM
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| 4 |
EC50 = 0.315 nM
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| 5 |
EC50 = 0.32 nM
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CP0912324
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methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C42H51N9O7
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3
|
| 1 |
EC50 = 0.022 nM
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| 2 |
EC50 = 0.1 nM
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| 3 |
EC50 = 1.6 nM
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CP0960265
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methyl N-[(S)-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-tetrahydropyran-4-yl-methyl]carbamate
Show/Hide
|
C44H53N9O7
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3
|
| 1 |
EC50 = 0.023 nM
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| 2 |
EC50 = 0.05 nM
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| 3 |
EC50 = 0.86 nM
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CP0867224
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benzyl N-[(3R)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]-3-piperidyl]carbamate
Show/Hide
|
C45H49N7O5
|
2
|
| 1 |
EC50 = 0.023 nM
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| 2 |
EC50 = 100 nM
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CP0946300
|
methyl N-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-3H-imidazo[4,5-b]pyridin-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
3
|
| 1 |
EC50 = 0.025 nM
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|
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| 2 |
EC50 = 0.08 nM
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|
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| 3 |
EC50 = 2.1 nM
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CP0867225
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benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-(4-benzamidophenyl)phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
Show/Hide
|
C46H44N6O5
|
2
|
| 1 |
EC50 = 0.025 nM
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|
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| 2 |
EC50 = 34 nM
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CP0955137
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methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-imidazo[4,5-b]pyridin-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
3
|
| 1 |
EC50 = 0.026 nM
|
|
|
| 2 |
EC50 = 0.23 nM
|
|
|
| 3 |
EC50 = 6.6 nM
|
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CP0029881
|
ABT-267
Show/Hide
|
C50H67N7O8
|
3
|
| 1 |
EC50 = 0.03 nM
|
|
|
| 2 |
EC50 = 0.086 nM
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|
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| 3 |
EC50 = 3.392 nM
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CP0904046
|
methyl N-[(1S)-2-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S)-1-(methoxycarbonylamino)-2-methyl-propyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-tetrahydropyran-4-yl-ethyl]carbamate
Show/Hide
|
C44H53N9O7
|
3
|
| 1 |
EC50 = 0.03 nM
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| 2 |
EC50 = 0.08 nM
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|
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| 3 |
EC50 = 0.89 nM
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|
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CP0644596
|
LEDIPASVIR
Show/Hide
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C49H54F2N8O6
|
27
|
| 1 |
EC50 = 0.031 nM
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|
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| 2 |
EC50 = 0.15 nM
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|
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| 3 |
EC50 = 0.39 nM
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|
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| 4 |
EC50 = 1.1 nM
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|
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| 5 |
EC50 = 1.9 nM
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|
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| 6 |
EC50 = 5.7 nM
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| 7 |
EC50 = 7.2 nM
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| 8 |
EC50 = 17 nM
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| 9 |
EC50 = 19.6 nM
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|
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| 10 |
EC50 = 21 nM
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| 11 |
EC50 = 49.6 nM
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| 12 |
EC50 = 52 nM
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| 13 |
EC50 = 123 nM
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| 14 |
EC50 = 164 nM
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| 15 |
EC50 = 168 nM
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| 16 |
EC50 = 169 nM
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| 17 |
EC50 = 209 nM
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| 18 |
EC50 = 211 nM
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| 19 |
EC50 = 222 nM
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| 20 |
EC50 = 249 nM
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| 21 |
EC50 = 264 nM
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| 22 |
EC50 = 292 nM
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| 23 |
EC50 = 530 nM
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|
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| 24 |
EC50 = 865 nM
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| 25 |
EC50 = 943 nM
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|
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| 26 |
EC50 > 44.8 nM
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| 27 |
EC50 > 88.8 nM
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CP0867644
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methyl N-[(1R)-2-[(2S)-2-[5-[13-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C45H48N8O8
|
5
|
| 1 |
EC50 = 0.031 nM
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|
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| 2 |
EC50 = 0.05 nM
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|
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| 3 |
EC50 = 0.076 nM
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|
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| 4 |
EC50 = 0.6 nM
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| 5 |
EC50 = 1.82 nM
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CP0556565
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N-[(1R)-2-oxo-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(pentanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-phenylethyl]pentanamide
Show/Hide
|
C52H56N6O4S2
|
1
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| 1 |
EC50 = 0.031 nM
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|
|
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CP0563259
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(pyrrolidine-1-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyrrolidine-1-carboxamide
Show/Hide
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C52H54N8O4S2
|
1
|
| 1 |
EC50 = 0.035 nM
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|
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CP0870599
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benzyl N-[(3S)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]pyrrolidin-3-yl]carbamate
Show/Hide
|
C44H47N7O5
|
2
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| 1 |
EC50 = 0.037 nM
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|
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| 2 |
EC50 = 82 nM
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CP0951318
|
methyl N-[2-[(2S)-2-[5-[13-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaen-6-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-pyridin-3-ylethyl]carbamate
Show/Hide
|
C44H47N9O8
|
5
|
| 1 |
EC50 = 0.038 nM
|
|
|
| 2 |
EC50 = 0.58 nM
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|
|
| 3 |
EC50 = 0.75 nM
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|
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| 4 |
EC50 = 1.21 nM
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|
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| 5 |
EC50 = 1.8 nM
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CP0402430
|
methyl N-[(2S)-1-[(2S)-2-[[4-[(2R,5R)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-triethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C52H73N7O8Si
|
1
|
| 1 |
EC50 = 0.041 nM
|
|
|
|
CP0962188
|
methyl N-[(1S)-1-[[(2S)-2-[6-[2-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-6-quinolyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
2
|
| 1 |
EC50 = 0.041 nM
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|
|
| 2 |
EC50 = 2.03 nM
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|
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CP0869645
|
methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-quinolyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
3
|
| 1 |
EC50 = 0.042 nM
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|
|
| 2 |
EC50 = 0.26 nM
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|
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| 3 |
EC50 = 1.1 nM
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CP0867226
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methyl N-[(3R)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]pyrrolidin-3-yl]carbamate
Show/Hide
|
C38H43N7O5
|
2
|
| 1 |
EC50 = 0.043 nM
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|
|
| 2 |
EC50 = 353 nM
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|
|
|
CP0955136
|
methyl N-[(1S)-1-[[(2S)-2-[6-[3-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-7-quinolyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
2
|
| 1 |
EC50 = 0.046 nM
|
|
|
| 2 |
EC50 = 1.3 nM
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|
|
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CP0869649
|
methyl N-[(1S,2R)-2-methoxy-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]propyl]carbamate
Show/Hide
|
C42H51N9O8
|
3
|
| 1 |
EC50 = 0.047 nM
|
|
|
| 2 |
EC50 = 0.13 nM
|
|
|
| 3 |
EC50 = 1.5 nM
|
|
|
|
CP0896994
|
methyl N-[(1S)-1-[[(2S)-2-[6-[5-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-1-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C42H51N9O6
|
2
|
| 1 |
EC50 = 0.05 nM
|
|
|
| 2 |
EC50 = 39.7 nM
|
|
|
|
CP0894987
|
methyl N-[(S)-cyclopentyl-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-cyclopentyl-2-(methoxycarbonylamino)acetyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]methyl]carbamate
Show/Hide
|
C46H55N9O6
|
2
|
| 1 |
EC50 = 0.05 nM
|
|
|
| 2 |
EC50 = 2.4 nM
|
|
|
|
CP0701915
|
Daclatasvir
Show/Hide
|
C40H51N9O6
|
4
|
| 1 |
EC50 = 0.05 nM
|
|
|
| 2 |
EC50 = 0.073 nM
|
|
|
| 3 |
EC50 = 0.14 nM
|
|
|
| 4 |
EC50 = 0.67 nM
|
|
|
|
CP0962189
|
methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-imidazo[4,5-c]pyridin-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
3
|
| 1 |
EC50 = 0.052 nM
|
|
|
| 2 |
EC50 = 1.2 nM
|
|
|
| 3 |
EC50 = 15.4 nM
|
|
|
|
CP0869646
|
methyl N-[(1S)-1-[[(2S)-2-[6-[7-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-3-isoquinolyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C41H50N10O6
|
2
|
| 1 |
EC50 = 0.053 nM
|
|
|
| 2 |
EC50 = 0.68 nM
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|
|
|
CP0575374
|
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(hexanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]hexanamide
Show/Hide
|
C54H60N6O4S2
|
1
|
| 1 |
EC50 = 0.063 nM
|
|
|
|
CP0575372
|
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(furan-2-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]furan-2-carboxamide
Show/Hide
|
C52H44N6O6S2
|
1
|
| 1 |
EC50 = 0.07 nM
|
|
|
|
CP0941213
|
dimethyl (1S,1'S)-2,2'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethane-2,1-diyl)dicarbamate
Show/Hide
|
C46H54N8O10
|
5
|
| 1 |
EC50 = 0.074 nM
|
|
|
| 2 |
EC50 = 0.33 nM
|
|
|
| 3 |
EC50 = 0.38 nM
|
|
|
| 4 |
EC50 = 0.6 nM
|
|
|
| 5 |
EC50 = 0.8 nM
|
|
|
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CP0869644
|
methyl N-[(1S)-1-[[(3R)-3-[6-[6-[2-[(3R)-4-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]morpholin-3-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]morpholine-4-carbonyl]amino]-2-methyl-propyl]carbamate
Show/Hide
|
C42H51N9O8
|
2
|
| 1 |
EC50 = 0.074 nM
|
|
|
| 2 |
EC50 = 2.85 nM
|
|
|
|
CP0867223
|
benzyl N-[3-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]phenyl]carbamate
Show/Hide
|
C46H44N6O5
|
2
|
| 1 |
EC50 = 0.076 nM
|
|
|
| 2 |
EC50 = 44 nM
|
|
|
|
CP0556562
|
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(furan-3-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]furan-3-carboxamide
Show/Hide
|
C52H44N6O6S2
|
1
|
| 1 |
EC50 = 0.08 nM
|
|
|
|
CP0907324
|
methyl N-[(S)-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-2-tetrahydropyran-4-yl-acetyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-tetrahydropyran-4-yl-methyl]carbamate
Show/Hide
|
C46H55N9O8
|
3
|
| 1 |
EC50 = 0.113 nM
|
|
|
| 2 |
EC50 = 0.13 nM
|
|
|
| 3 |
EC50 = 1.1 nM
|
|
|
|
CP0474106
|
methyl N-[(2S)-1-[(2S)-2-[[4-[(2R,5R)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-trimethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
|
C49H67N7O8Si
|
1
|
| 1 |
EC50 = 0.118 nM
|
|
|
|
CP0434255
|
N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-[(2-phenylacetyl)amino]acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-2-phenylacetamide
Show/Hide
|
C58H52N6O4S2
|
1
|
| 1 |
EC50 = 0.13 nM
|
|
|
|
CP0556563
|
N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(pyridine-3-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-3-carboxamide
Show/Hide
|
C54H46N8O4S2
|
1
|
| 1 |
EC50 = 0.13 nM
|
|
|
|
CP0901622
|
benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
Show/Hide
|
C43H46N6O5
|
2
|
| 1 |
EC50 = 0.15 nM
|
|
|
| 2 |
EC50 = 56 nM
|
|
|
|
CP0575364
|
methyl N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
|
C46H44N6O6S2
|
1
|
| 1 |
EC50 = 0.19 nM
|
|
|
|
CP0869643
|
methyl N-[(1S,2R)-2-hydroxy-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-hydroxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]propyl]carbamate
Show/Hide
|
C40H47N9O8
|
2
|
| 1 |
EC50 = 0.19 nM
|
|
|
| 2 |
EC50 = 0.43 nM
|
|
|
|
CP0550940
|
3-morpholin-4-yl-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(3-morpholin-4-ylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
|
C56H62N8O6S2
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0556557
|
N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(3-pyrrol-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-pyrrol-1-ylpropanamide
Show/Hide
|
C56H54N8O4S2
|
1
|
| 1 |
EC50 = 0.23 nM
|
|
|
|
CP0562018
|
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclohexanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclohexanecarboxamide
Show/Hide
|
C56H60N6O4S2
|
1
|
| 1 |
EC50 = 0.25 nM
|
|
|
|
CP0561767
|
2-methyl-N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(2-methylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
|
C50H52N6O4S2
|
1
|
| 1 |
EC50 = 0.31 nM
|
|
|
|
CP0957886
|
methyl N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamate
Show/Hide
|
C33H35N5O4
|
2
|
| 1 |
EC50 = 0.34 nM
|
|
|
| 2 |
EC50 = 2800 nM
|
|
|
|
CP0437982
|
N-[(1S)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(pyridine-4-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-4-carboxamide
Show/Hide
|
C54H46N8O4S2
|
1
|
| 1 |
EC50 = 0.37 nM
|
|
|
|
CP0572923
|
N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclobutanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclobutanecarboxamide
Show/Hide
|
C52H52N6O4S2
|
1
|
| 1 |
EC50 = 0.45 nM
|
|
|
|
CP0564669
|
N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(thiophene-3-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]thiophene-3-carboxamide
Show/Hide
|
C52H44N6O4S4
|
1
|
| 1 |
EC50 = 0.53 nM
|
|
|
|
CP0382936
|
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-acetamido-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]acetamide
Show/Hide
|
C46H44N6O4S2
|
1
|
| 1 |
EC50 = 0.59 nM
|
|
|
|
CP0904045
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methyl N-[(1S,2R)-1-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S,2R)-1-(methoxycarbonylamino)-2-methyl-butyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-butyl]carbamate
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C44H55N9O6
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2
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| 1 |
EC50 = 0.6 nM
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| 2 |
EC50 = 9.5 nM
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CP0434254
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(furan-3-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]furan-3-carboxamide
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C52H44N6O6S2
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1
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| 1 |
EC50 = 0.63 nM
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CP0575369
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(butanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]butanamide
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C50H52N6O4S2
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1
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| 1 |
EC50 = 0.77 nM
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CP0443827
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(propanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]propanamide
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C48H48N6O4S2
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1
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| 1 |
EC50 = 0.85 nM
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CP0563258
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(3-piperidin-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-piperidin-1-ylpropanamide
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C58H66N8O4S2
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1
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| 1 |
EC50 = 0.89 nM
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CP0561769
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3-(diethylamino)-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-[3-(diethylamino)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
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C56H66N8O4S2
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1
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| 1 |
EC50 = 1 nM
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CP0563257
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopentanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclopentanecarboxamide
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C54H56N6O4S2
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1
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| 1 |
EC50 = 1.1 nM
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CP0867438
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benzyl N-[(3R)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]pyrrolidin-3-yl]carbamate
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C44H47N7O5
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1
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| 1 |
EC50 = 1.1 nM
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CP0426216
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(morpholine-4-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]morpholine-4-carboxamide
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C52H54N8O6S2
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1
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| 1 |
EC50 = 1.13 nM
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CP0550938
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(pyrrolidine-1-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyrrolidine-1-carboxamide
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C52H54N8O4S2
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1
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| 1 |
EC50 = 1.3 nM
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CP0550941
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(2,2-dimethylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]-2,2-dimethylpropanamide
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C52H56N6O4S2
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1
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| 1 |
EC50 = 1.35 nM
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CP0556561
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(thiophene-2-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]thiophene-2-carboxamide
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C52H44N6O4S4
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1
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| 1 |
EC50 = 1.43 nM
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CP0535190
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(cyclopropanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclopropanecarboxamide
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C50H48N6O4S2
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1
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| 1 |
EC50 = 1.5 nM
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CP0575368
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(furan-2-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]furan-2-carboxamide
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C52H44N6O6S2
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1
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| 1 |
EC50 = 1.7 nM
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CP0440016
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(piperidine-1-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]piperidine-1-carboxamide
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C54H58N8O4S2
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1
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| 1 |
EC50 = 1.9 nM
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CP0535188
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(pyridine-3-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-3-carboxamide
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C54H46N8O4S2
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1
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| 1 |
EC50 = 2.1 nM
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CP0556560
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(hexanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]hexanamide
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C54H60N6O4S2
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1
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| 1 |
EC50 = 2.37 nM
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CP0561770
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3-(dimethylamino)-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-[3-(dimethylamino)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
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C52H58N8O4S2
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1
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| 1 |
EC50 = 2.5 nM
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CP0440014
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3-morpholin-4-yl-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(3-morpholin-4-ylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
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C56H62N8O6S2
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1
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| 1 |
EC50 = 2.6 nM
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CP0556559
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N-[(1S)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-[(2-phenylacetyl)amino]acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-2-phenylacetamide
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C58H52N6O4S2
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1
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| 1 |
EC50 = 2.87 nM
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CP0426210
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(methanesulfonamido)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]methanesulfonamide
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C44H44N6O6S4
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1
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| 1 |
EC50 = 3.4 nM
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CP0938046
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benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-[[4-(methoxymethyl)benzoyl]amino]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
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C48H48N6O6
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1
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| 1 |
EC50 = 3.5 nM
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CP0408720
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(3S,5S)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
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C23H25FN2O7S2
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1
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| 1 |
EC50 = 4 nM
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CP0561768
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(3-pyrrolidin-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-pyrrolidin-1-ylpropanamide
Show/Hide
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C56H62N8O4S2
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1
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| 1 |
EC50 = 4 nM
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CP0389215
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HCV 796
Show/Hide
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C22H23FN2O5S
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2
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| 1 |
EC50 = 5 nM
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| 2 |
EC50 = 24 nM
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CP0562016
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3-(dimethylamino)-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[3-(dimethylamino)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
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C52H58N8O4S2
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1
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| 1 |
EC50 = 6.9 nM
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CP0440041
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3-(4-methylpiperazin-1-yl)-N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-[3-(4-methylpiperazin-1-yl)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
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C58H68N10O4S2
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1
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| 1 |
EC50 = 7.2 nM
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CP0553981
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N-[(1R)-2-oxo-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(pentanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-phenylethyl]pentanamide
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C52H56N6O4S2
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1
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| 1 |
EC50 = 7.6 nM
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CP0930995
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benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-[(4-methoxycyclohexanecarbonyl)amino]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
Show/Hide
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C47H52N6O6
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1
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| 1 |
EC50 = 8.1 nM
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CP0408709
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(5R)-2-(4-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H23FN2O4S
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2
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| 1 |
EC50 = 9 nM
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| 2 |
EC50 = 10 nM
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CP0438358
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(5S)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C21H21FN2O5S
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1
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| 1 |
EC50 = 9 nM
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CP0410299
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C23H25FN2O7S2
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1
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| 1 |
EC50 = 9 nM
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CP0547800
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(3S,5S)-8-(4-fluorophenyl)-3-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 = 9 nM
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CP0440792
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2-(4-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H23FN2O4S
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1
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| 1 |
EC50 = 10 nM
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CP0561428
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2-(2-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H23FN2O4S
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1
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| 1 |
EC50 = 11 nM
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CP0427229
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(5S)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-oxo-4,5-dihydro-2H-furo[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C21H20FN3O5S
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1
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| 1 |
EC50 = 11 nM
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CP0408747
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-oxo-4,5-dihydro-2H-furo[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C21H20FN3O5S
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2
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| 1 |
EC50 = 14 nM
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| 2 |
EC50 = 19 nM
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CP0545948
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2-(2,4-difluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H22F2N2O4S
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1
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| 1 |
EC50 = 15 nM
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CP0440015
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(3-piperidin-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-piperidin-1-ylpropanamide
Show/Hide
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C58H66N8O4S2
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1
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| 1 |
EC50 = 15.6 nM
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CP0440794
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-2-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C23H25FN2O7S2
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1
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| 1 |
EC50 = 16 nM
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CP0556656
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(2S)-14-(4-fluorophenyl)-N,2-dimethyl-9-methylsulfonyl-13-oxa-3,4,5,9-tetrazatetracyclo[8.7.0.03,7.012,16]heptadeca-1(10),4,6,11,14,16-hexaene-15-carboxamide
Show/Hide
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C22H20FN5O4S
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1
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| 1 |
EC50 = 20 nM
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CP0535192
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N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-benzamido-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]benzamide
Show/Hide
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C56H48N6O4S2
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1
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| 1 |
EC50 = 20.8 nM
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CP0427222
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C21H21FN2O5S
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2
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| 1 |
EC50 = 21 nM
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| 2 |
EC50 = 28 nM
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CP0575367
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3-(diethylamino)-N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-[3-(diethylamino)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
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C56H66N8O4S2
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1
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| 1 |
EC50 = 22.4 nM
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CP0549483
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N-[(1S)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(3-pyrrolidin-1-ylpropanoylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]-3-pyrrolidin-1-ylpropanamide
Show/Hide
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C56H62N8O4S2
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1
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| 1 |
EC50 = 22.6 nM
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CP0547797
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(10R,12R)-5-(4-fluorophenyl)-N-methyl-15-methylsulfonyl-4-oxa-15-azatetracyclo[7.6.0.03,7.010,12]pentadeca-1(9),2,5,7-tetraene-6-carboxamide
Show/Hide
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C22H21FN2O4S
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1
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| 1 |
EC50 = 25 nM
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CP0410292
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14-(4-fluorophenyl)-N,2-dimethyl-9-methylsulfonyl-13-oxa-3,6,9-triazatetracyclo[8.7.0.03,7.012,16]heptadeca-1(10),4,6,11,14,16-hexaene-15-carboxamide
Show/Hide
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C23H21FN4O4S
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1
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| 1 |
EC50 = 26 nM
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CP0402274
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)-4-methylpentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]cyclopropanecarboxamide
Show/Hide
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C46H56N6O4S2
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1
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| 1 |
EC50 = 27.1 nM
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CP0444355
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2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine
Show/Hide
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C22H20FN3O3S
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2
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| 1 |
EC50 = 33 nM
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| 2 |
EC50 = 59 nM
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CP0563700
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8-(4-fluorophenyl)-N,3,5-trimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O5S
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1
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| 1 |
EC50 = 33 nM
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CP0396138
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5-(4-fluorophenyl)-N-methyl-15-methylsulfonyl-4-oxa-15-azatetracyclo[7.6.0.03,7.010,12]pentadeca-1(9),2,5,7-tetraene-6-carboxamide
Show/Hide
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C22H21FN2O4S
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2
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| 1 |
EC50 = 35 nM
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| 2 |
EC50 = 44 nM
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CP0535189
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclohexanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclohexanecarboxamide
Show/Hide
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C56H60N6O4S2
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1
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| 1 |
EC50 = 39.8 nM
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CP0410298
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8-(4-fluorophenyl)-2-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 = 40 nM
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CP0564668
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methyl N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
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C46H44N6O6S2
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1
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| 1 |
EC50 = 40.9 nM
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CP0535191
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(pyridine-2-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-2-carboxamide
Show/Hide
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C54H46N8O4S2
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1
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| 1 |
EC50 = 46.3 nM
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CP0410280
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8-(4-fluorophenyl)-N,4,5-trimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C22H24FN3O4S
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1
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| 1 |
EC50 = 50 nM
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CP0422901
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8-(4-fluorophenyl)-3-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 = 52 nM
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CP0561766
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(2,2-dimethylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]-2,2-dimethylpropanamide
Show/Hide
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C52H56N6O4S2
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1
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| 1 |
EC50 = 52 nM
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CP0545950
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14-(4-fluorophenyl)-N,2-dimethyl-9-methylsulfonyl-13-oxa-3,4,5,9-tetrazatetracyclo[8.7.0.03,7.012,16]heptadeca-1(10),4,6,11,14,16-hexaene-15-carboxamide
Show/Hide
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C22H20FN5O4S
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1
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| 1 |
EC50 = 54 nM
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CP0440012
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C40H48N6O6S2
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1
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| 1 |
EC50 = 56.3 nM
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CP0563256
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamate
Show/Hide
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C38H44N6O6S2
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1
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| 1 |
EC50 = 56.6 nM
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CP0545952
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(3R,5S)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C23H25FN2O7S2
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1
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| 1 |
EC50 = 57 nM
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CP0937963
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methyl N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[4-(4-phenylphenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]ethyl]carbamate
Show/Hide
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C29H28N4O3
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2
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| 1 |
EC50 = 57 nM
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| 2 |
EC50 = 2800 nM
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CP0410283
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(3R,5S)-8-(4-fluorophenyl)-3-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 = 64 nM
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CP0410296
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2-(4-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-7,8-dihydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H21FN2O4S
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1
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| 1 |
EC50 = 70 nM
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CP0556654
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2-[4-(4-fluorophenoxy)phenyl]-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C28H27FN2O5S
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1
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| 1 |
EC50 = 71 nM
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CP0408325
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2-(4-fluorophenyl)-N-methyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C21H21FN2O4S
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1
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| 1 |
EC50 = 83 nM
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CP0562548
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(5S)-2-(4-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H23FN2O4S
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1
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| 1 |
EC50 = 89 nM
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CP0563693
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2-(4-fluorophenyl)-N-methoxy-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C21H21FN2O5S
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1
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| 1 |
EC50 = 90 nM
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CP0561764
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)pentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopentan-2-yl]cyclopropanecarboxamide
Show/Hide
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C44H52N6O4S2
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1
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| 1 |
EC50 = 91.7 nM
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CP0410286
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(5S)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonylspiro[2,5-dihydrofuro[3,2-h][4,1]benzoxazepine-3,1'-cyclopropane]-7-carboxamide
Show/Hide
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C23H23FN2O5S
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1
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| 1 |
EC50 = 93 nM
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CP0408706
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(3S,5R)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C23H25FN2O7S2
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1
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| 1 |
EC50 = 100 nM
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CP0410278
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14-(4-fluorophenyl)-N,2-dimethyl-9-methylsulfonyl-13-oxa-3,4,5,6,9-pentazatetracyclo[8.7.0.03,7.012,16]heptadeca-1(10),4,6,11,14,16-hexaene-15-carboxamide
Show/Hide
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C21H19FN6O4S
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1
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| 1 |
EC50 = 100 nM
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CP0382935
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3-(4-methylpiperazin-1-yl)-N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-[3-(4-methylpiperazin-1-yl)propanoylamino]-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
Show/Hide
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C58H68N10O4S2
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1
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| 1 |
EC50 = 101.8 nM
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CP0558815
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(5S)-8-(4-fluorophenyl)-N,4,5-trimethyl-1-methylsulfonyl-3-oxo-2,5-dihydrofuro[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C22H22FN3O5S
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1
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| 1 |
EC50 = 102 nM
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CP0408319
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2-(4-fluorophenyl)-N-methyl-5-methylidene-9-methylsulfonyl-7,8-dihydro-6H-furo[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H21FN2O4S
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1
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| 1 |
EC50 = 106 nM
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CP0540897
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methyl N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
Show/Hide
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C46H44N6O6S2
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1
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| 1 |
EC50 = 107.9 nM
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CP0421076
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N-[(1S)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(thiophene-2-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]thiophene-2-carboxamide
Show/Hide
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C52H44N6O4S4
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1
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| 1 |
EC50 = 109.8 nM
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CP0575366
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)propanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopropan-2-yl]cyclopropanecarboxamide
Show/Hide
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C40H44N6O4S2
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1
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| 1 |
EC50 = 115.4 nM
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CP0561427
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2-(4-fluorophenyl)-N-methyl-9-methylsulfonylspiro[7,8-dihydro-6H-furo[3,2-h][1]benzazepine-5,1'-cyclopropane]-3-carboxamide
Show/Hide
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C23H23FN2O4S
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1
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| 1 |
EC50 = 118 nM
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CP0402275
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(thiophene-3-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]thiophene-3-carboxamide
Show/Hide
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C52H44N6O4S4
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1
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| 1 |
EC50 = 122.3 nM
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CP0402272
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)pentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate
Show/Hide
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C40H48N6O6S2
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1
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| 1 |
EC50 = 123.1 nM
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CP0410287
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonylspiro[2,5-dihydrofuro[3,2-h][4,1]benzoxazepine-3,1'-cyclopropane]-7-carboxamide
Show/Hide
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C23H23FN2O5S
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1
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| 1 |
EC50 = 130 nM
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CP0870598
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benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]phenyl]carbamate
Show/Hide
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C46H44N6O5
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1
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| 1 |
EC50 = 131 nM
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CP0572924
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(methanesulfonamido)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]methanesulfonamide
Show/Hide
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C44H44N6O6S4
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1
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| 1 |
EC50 = 149.3 nM
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CP0547985
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)propanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
Show/Hide
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C36H40N6O6S2
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1
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| 1 |
EC50 = 158.5 nM
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CP0549482
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-4-methylpentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
Show/Hide
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C42H52N6O6S2
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1
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| 1 |
EC50 = 179 nM
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CP0475810
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8-(4-fluorophenyl)-N,4,5-trimethyl-1-methylsulfonyl-3-oxo-2,5-dihydrofuro[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C22H22FN3O5S
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1
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| 1 |
EC50 = 180 nM
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CP0561763
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)hexanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamate
Show/Hide
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C42H52N6O6S2
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1
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| 1 |
EC50 = 236.5 nM
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CP0960462
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benzyl N-[(3S)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]-3-piperidyl]carbamate
Show/Hide
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C45H49N7O5
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1
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| 1 |
EC50 = 247 nM
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CP0475811
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8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-2,3,4,5-tetrahydrofuro[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C21H22FN3O4S
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1
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| 1 |
EC50 = 265 nM
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CP0550939
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N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-benzamido-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]benzamide
Show/Hide
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C56H48N6O4S2
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1
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| 1 |
EC50 = 271.9 nM
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CP0440791
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2-(4-fluorophenyl)-N-methyl-9-methylsulfonyl-5-oxo-7,8-dihydro-6H-furo[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C21H19FN2O5S
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1
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| 1 |
EC50 = 318 nM
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CP0549481
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ethyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(ethoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Show/Hide
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C42H52N6O6S2
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1
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| 1 |
EC50 = 327.1 nM
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CP0556657
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9-cyclopropylsulfonyl-2-(4-fluorophenyl)-N-methyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C23H23FN2O4S
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2
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| 1 |
EC50 = 335 nM
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| 2 |
EC50 = 423 nM
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CP0965421
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N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]pyrrolidine-1-carboxamide
Show/Hide
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C36H40N6O3
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1
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| 1 |
EC50 = 353 nM
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CP0440013
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)hexanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxohexan-2-yl]cyclopropanecarboxamide
Show/Hide
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C46H56N6O4S2
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1
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| 1 |
EC50 = 358 nM
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CP0561765
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)butanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]cyclopropanecarboxamide
Show/Hide
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C42H48N6O4S2
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1
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| 1 |
EC50 = 433.4 nM
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CP0575365
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methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Show/Hide
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C42H52N6O6S2
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1
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| 1 |
EC50 = 470.8 nM
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CP0475808
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5-(4-fluorophenyl)-N,10-dimethyl-14-methylsulfonyl-3,4,14-triazatricyclo[7.5.0.03,7]tetradeca-1,4,6,8-tetraene-6-carboxamide
Show/Hide
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C21H23FN4O3S
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1
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| 1 |
EC50 = 523 nM
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CP0410284
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(3S,5R)-8-(4-fluorophenyl)-3-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 = 554 nM
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CP0410281
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2-(4-fluorophenyl)-9-methylsulfonyl-3-(1H-1,2,4-triazol-5-yl)-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine
Show/Hide
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C21H19FN4O3S
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2
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| 1 |
EC50 = 605 nM
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| 2 |
EC50 >= 719 nM
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CP0944471
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benzyl N-[2-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]phenyl]carbamate
Show/Hide
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C46H44N6O5
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1
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| 1 |
EC50 = 614 nM
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CP0410277
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(2R)-14-(4-fluorophenyl)-N,2-dimethyl-9-methylsulfonyl-13-oxa-3,4,5,9-tetrazatetracyclo[8.7.0.03,7.012,16]heptadeca-1(10),4,6,11,14,16-hexaene-15-carboxamide
Show/Hide
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C22H20FN5O4S
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1
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| 1 |
EC50 = 617 nM
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CP0408707
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(5R)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C21H21FN2O5S
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1
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| 1 |
EC50 = 624 nM
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CP0904638
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N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]-7-phenyl-heptanamide
Show/Hide
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C44H49N5O3
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1
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| 1 |
EC50 = 642 nM
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CP0408705
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(5R)-8-(4-fluorophenyl)-N,4,5-trimethyl-1-methylsulfonyl-3-oxo-2,5-dihydrofuro[3,2-h][1,4]benzodiazepine-7-carboxamide
Show/Hide
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C22H22FN3O5S
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1
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| 1 |
EC50 = 688 nM
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CP0561438
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methyl 2-(4-fluorophenyl)-3-(methylcarbamoyl)-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-9-carboxylate
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C22H21FN2O4
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1
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| 1 |
EC50 = 722 nM
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CP0408708
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2-(4-fluorophenyl)-5-hydroxy-N-methyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C21H21FN2O5S
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1
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| 1 |
EC50 = 730 nM
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CP0434315
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopropanecarboxamide
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C44H52N6O4S2
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1
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| 1 |
EC50 = 731.9 nM
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CP0560073
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5-(4-fluorophenyl)-N,14-dimethyl-10-methylsulfonyl-3,6,10-triazatricyclo[7.5.0.03,7]tetradeca-1,4,6,8-tetraene-4-carboxamide
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C21H23FN4O3S
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1
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| 1 |
EC50 = 801 nM
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CP0867222
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N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]-4-phenyl-butanamide
Show/Hide
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C41H43N5O3
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1
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| 1 |
EC50 = 1300 nM
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CP0402273
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N-[(2R)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopropanecarbonylamino)-3,3-dimethylbutanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]cyclopropanecarboxamide
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C46H56N6O4S2
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1
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| 1 |
EC50 = 1603 nM
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CP0545949
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(5R)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-oxo-4,5-dihydro-2H-furo[3,2-h][1,4]benzodiazepine-7-carboxamide
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C21H20FN3O5S
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1
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| 1 |
EC50 = 1795 nM
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CP0957885
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N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]benzamide
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C38H37N5O3
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1
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| 1 |
EC50 = 2400 nM
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CP0556558
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N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-phenyl-2-(pyridine-2-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]pyridine-2-carboxamide
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C54H46N8O4S2
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1
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| 1 |
EC50 = 2635.9 nM
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CP0560777
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phenyl N-[(2S)-3-methyl-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-3-methyl-2-(phenoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamate
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C50H52N6O6S2
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1
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| 1 |
EC50 = 2815.6 nM
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CP0938045
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methyl N-[(1R)-2-[(2S)-2-(1H-imidazol-2-yl)pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamate
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C17H20N4O3
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1
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| 1 |
EC50 > 10000 nM
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CP0434314
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N-[(1R)-1-cyclohexyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-cyclohexyl-2-(cyclopropanecarbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]cyclopropanecarboxamide
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C50H60N6O4S2
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1
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| 1 |
EC50 > 50000 nM
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CP0488082
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methyl N-[(2S)-1-[(2S)-2-[[4-[(2R,5S)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-triethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C52H73N7O8Si
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1
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| 1 |
EC50 > 0.5 nM
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CP0547108
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methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5R)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]-1-(4-trimethylsilylphenyl)pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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C49H67N7O8Si
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1
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| 1 |
EC50 > 0.5 nM
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CP0460692
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methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]naphthalen-1-yl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methylpropyl]carbamate
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C42H51N9O6
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2
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| 1 |
EC50 > 3.7 nM
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| 2 |
EC50 > 100 nM
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CP0862676
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2-(4-fluorophenyl)-9-(methylsulfonyl)-3-(1H-tetrazol-5-yl)-6,7,8,9-tetrahydro-5H-benzofuro[6,5-b]azepine
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C20H18FN5O3S
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2
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| 1 |
EC50 >= 480 nM
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| 2 |
EC50 >= 518 nM
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CP0408321
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3-(4,5-dihydro-1H-imidazol-2-yl)-2-(4-fluorophenyl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine
Show/Hide
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C22H22FN3O3S
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1
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| 1 |
EC50 > 2000 nM
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CP0408324
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2-(4-fluorophenyl)-N,9-bis(methylsulfonyl)-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C21H21FN2O6S2
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1
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| 1 |
EC50 > 2000 nM
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CP0408748
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2-(4-fluoro-2-methoxyphenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C23H25FN2O5S
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1
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| 1 |
EC50 > 2000 nM
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CP0422900
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2-(4-fluorophenyl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C20H19FN2O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0440790
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(10S,12S)-5-(4-fluorophenyl)-N-methyl-15-methylsulfonyl-4-oxa-15-azatetracyclo[7.6.0.03,7.010,12]pentadeca-1(9),2,5,7-tetraene-6-carboxamide
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C22H21FN2O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0444434
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2-(4-fluorophenyl)-N,N-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H23FN2O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0545954
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2-(4-fluorophenyl)-N-hydroxy-N-methyl-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C21H21FN2O5S
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1
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| 1 |
EC50 > 2000 nM
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CP0545955
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N-cyano-2-(4-fluorophenyl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C21H18FN3O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0559464
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N-cyclopropyl-2-(4-fluorophenyl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C23H23FN2O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0410279
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(3R,5R)-8-(4-fluorophenyl)-3-(hydroxymethyl)-N,5-dimethyl-1-methylsulfonyl-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C22H23FN2O6S
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1
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| 1 |
EC50 > 2000 nM
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CP0410282
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2-(4-fluorophenyl)-N,5-dimethyl-9-methylsulfonyl-5,6,7,8-tetrahydropyrazolo[4,3-h][1]benzazepine-3-carboxamide
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C21H23FN4O3S
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1
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| 1 |
EC50 > 2000 nM
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CP0422895
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9-acetyl-2-(4-fluorophenyl)-N-methyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
Show/Hide
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C22H21FN2O3
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1
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| 1 |
EC50 > 2000 nM
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CP0541325
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(3R,5R)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonyl-3-(methylsulfonylmethyl)-3,5-dihydro-2H-furo[3,2-h][4,1]benzoxazepine-7-carboxamide
Show/Hide
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C23H25FN2O7S2
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1
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| 1 |
EC50 > 2000 nM
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CP0545951
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(5R)-8-(4-fluorophenyl)-N,5-dimethyl-1-methylsulfonylspiro[2,5-dihydrofuro[3,2-h][4,1]benzoxazepine-3,1'-cyclopropane]-7-carboxamide
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C23H23FN2O5S
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1
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| 1 |
EC50 > 2000 nM
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CP0547798
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N-ethyl-2-(4-fluorophenyl)-9-methylsulfonyl-5,6,7,8-tetrahydrofuro[3,2-h][1]benzazepine-3-carboxamide
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C22H23FN2O4S
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1
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| 1 |
EC50 > 2000 nM
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CP0947390
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Methyl {(S)-1-[(S)-2-(5-{4'-tert-butyl-6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C51H58Cl2N8O6
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4
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| 1 |
IC50 = 0.0103 nM
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| 2 |
IC50 = 0.362 nM
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| 3 |
IC50 = 0.693 nM
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| 4 |
IC50 = 2.296 nM
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CP0916064
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Methyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((R)-2-methoxycarbonylamino-2-phenylacetyl)pyrrolidin-2-yl]-3H-imidazol-4-yl}buta-1,3-diynyl)-3-(methylphenylamino)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
Show/Hide
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C48H53Cl2N9O6
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5
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| 1 |
IC50 = 0.0106 nM
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| 2 |
IC50 = 0.011 nM
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| 3 |
IC50 = 0.027 nM
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| 4 |
IC50 = 0.035 nM
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| 5 |
IC50 = 0.072 nM
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CP0922714
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Methyl {(S)-1-[(S)-2-(5-{4'-(dimethylamino)-6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
Show/Hide
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C49H55Cl2N9O6
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5
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| 1 |
IC50 = 0.0108 nM
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| 2 |
IC50 = 0.0128 nM
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| 3 |
IC50 = 0.038 nM
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| 4 |
IC50 = 0.052 nM
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| 5 |
IC50 = 0.138 nM
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CP0911502
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Methyl [(S)-1-((S)-2-{5-[4-(4'-tert-butyl-5-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}biphenyl-2-yl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
Show/Hide
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C48H62Cl4N8O6
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5
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| 1 |
IC50 = 0.011 nM
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| 2 |
IC50 = 0.356 nM
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| 3 |
IC50 = 0.642 nM
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| 4 |
IC50 = 1.286 nM
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| 5 |
IC50 = 1.684 nM
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CP0911505
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Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-1,1':3',1''-terphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
Show/Hide
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C53H54Cl2N8O6
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5
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| 1 |
IC50 = 0.011 nM
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| 2 |
IC50 = 0.033 nM
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| 3 |
IC50 = 0.122 nM
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| 4 |
IC50 = 0.123 nM
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| 5 |
IC50 = 0.626 nM
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CP0911509
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Methyl {(R)-1-[(S)-2-(5-{[4-(2-{(S)-1-[(S)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)phenyl]buta-1,3-diynyl}-1H-imidazol-2-yl)pyrrolidine-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate dihydrochloride
Show/Hide
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C41H46Cl2N8O6
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4
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| 1 |
IC50 = 0.0116 nM
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| 2 |
IC50 = 0.1 nM
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| 3 |
IC50 = 0.21 nM
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| 4 |
IC50 = 0.629 nM
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CP0911504
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Methyl {(1R)-2-[(2S)-2-{5-[4-(3-fluoro-5-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}biphenyl-2-yl)buta-1,3-diyn-1-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate dihydrochloride
Show/Hide
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C47H49Cl2FN8O6
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4
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| 1 |
IC50 = 0.0118 nM
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| 2 |
IC50 = 0.02 nM
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| 3 |
IC50 = 0.026 nM
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| 4 |
IC50 = 0.051 nM
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CP0911508
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Methyl {(S)-1-[(S)-2-(5-{[4-(2-{(S)-1-[(S)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)phenyl]buta-1,3-diynyl}-1H-imidazol-2-yl)pyrrolidine-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate dihydrochloride
Show/Hide
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C41H46Cl2N8O6
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6
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| 1 |
IC50 = 0.012 nM
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| 2 |
IC50 = 0.12 nM
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| 3 |
IC50 = 0.123 nM
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| 4 |
IC50 = 0.2 nM
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| 5 |
IC50 = 1.34 nM
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| 6 |
IC50 = 4.917 nM
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CP0922712
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methyl N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]buta-1,3-diynyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate dihydrochloride
Show/Hide
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C41H46Cl2N8O6
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6
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| 1 |
IC50 = 0.012 nM
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| 2 |
IC50 = 0.423 nM
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| 3 |
IC50 = 0.431 nM
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| 4 |
IC50 = 0.758 nM
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| 5 |
IC50 = 6.4 nM
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| 6 |
IC50 = 10.7 nM
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CP0911497
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Methyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((R)-2-methoxycarbonylamino-2-phenylacetyl)pyrrolidin-2-yl]-3H-imidazol-4-yl}buta-1,3-diynyl)-3-phenoxyphenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
Show/Hide
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C47H50Cl2N8O7
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4
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| 1 |
IC50 = 0.0126 nM
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| 2 |
IC50 = 0.019 nM
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| 3 |
IC50 = 0.04 nM
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| 4 |
IC50 = 0.214 nM
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CP0916928
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Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-5-methylbiphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
Show/Hide
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C48H52Cl2N8O6
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3
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| 1 |
IC50 = 0.013 nM
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| 2 |
IC50 = 0.026 nM
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| 3 |
IC50 = 0.124 nM
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CP0947389
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Methyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((R)-2-methoxycarbonylamino-2-phenylacetyl)pyrrolidin-2-yl]-3H-imidazol-4-yl}buta-1,3-diynyl)-3-phensulphanylphenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
Show/Hide
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C47H50Cl2N8O6S
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4
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| 1 |
IC50 = 0.0142 nM
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| 2 |
IC50 = 0.035 nM
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| 3 |
IC50 = 0.091 nM
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| 4 |
IC50 = 0.257 nM
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CP0922713
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Methyl {(S)-1-[(S)-2-(5-{[3-fluoro-5-(2-{(S)-1-[(S)-2-(methoxycarbonylamino)-3-methylbutyryl]pyrrolidin-2-yl}-1H-imidazol-5-yl)biphenyl-2-yl]buta-1,3-diynyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
Show/Hide
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C44H51Cl2FN8O6
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5
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| 1 |
IC50 = 0.0152 nM
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| 2 |
IC50 = 0.0192 nM
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| 3 |
IC50 = 0.064 nM
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| 4 |
IC50 = 0.12 nM
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| 5 |
IC50 = 0.459 nM
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CP0922711
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Methyl {(S)-1-[(S)-2-(5-{2',3'-difluoro-6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate
Show/Hide
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C47H46F2N8O6
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3
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| 1 |
IC50 = 0.016 nM
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| 2 |
IC50 = 0.019 nM
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| 3 |
IC50 = 0.028 nM
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CP0914439
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methyl N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]buta-1,3-diynyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate dihydrochloride
Show/Hide
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C41H46Cl2N8O6
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5
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| 1 |
IC50 = 0.016 nM
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| 2 |
IC50 = 0.036 nM
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| 3 |
IC50 = 0.126 nM
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| 4 |
IC50 = 0.276 nM
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| 5 |
IC50 = 0.329 nM
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CP0911507
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Methyl [(S)-1-((S)-2-{5-[4-(5-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}-[1,1';3',1'']terphenyl-2-yl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
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C50H56Cl2N8O6
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5
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| 1 |
IC50 = 0.0192 nM
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| 2 |
IC50 = 0.449 nM
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| 3 |
IC50 = 0.47 nM
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| 4 |
IC50 = 0.763 nM
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| 5 |
IC50 = 2.785 nM
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CP0911500
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Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-4'-(4-methylpiperazin-1-yl)biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C52H60Cl2N10O6
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5
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| 1 |
IC50 = 0.023 nM
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| 2 |
IC50 = 0.113 nM
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| 3 |
IC50 = 0.353 nM
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| 4 |
IC50 = 0.548 nM
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| 5 |
IC50 = 1.4 nM
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CP0916065
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Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C47H50Cl2N8O6
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4
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| 1 |
IC50 = 0.026 nM
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| 2 |
IC50 = 0.029 nM
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| 3 |
IC50 = 0.034 nM
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| 4 |
IC50 = 0.045 nM
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CP0916066
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Methyl {(S)-1-[(S)-2-(5-{[5-(2-{(S)-1-[(S)-2-(methoxycarbonylamino)-3-methylbutyryl]pyrrolidin-2-yl}-1H-imidazol-5-yl)-3-methylbiphenyl-2-yl]buta-1,3-diynyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate
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C45H54Cl2N8O6
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3
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| 1 |
IC50 = 0.027 nM
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| 2 |
IC50 = 0.037 nM
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| 3 |
IC50 = 0.364 nM
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CP0914438
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Methyl [(S)-1-((S)-2-{5-[(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-2-[naphthalen-2-yl]phenyl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
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C48H54Cl2N8O6
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4
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| 1 |
IC50 = 0.028 nM
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| 2 |
IC50 = 0.248 nM
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| 3 |
IC50 = 0.267 nM
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| 4 |
IC50 = 0.864 nM
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CP0870715
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US9428491, 1.1::US9428491, 1.1: 2HCl::US9428491, 1.1: naphtalene-1,5-disulfonic acid
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C38H46N8O6
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5
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| 1 |
IC50 = 0.028 nM
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| 2 |
IC50 = 0.084 nM
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| 3 |
IC50 = 0.215 nM
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| 4 |
IC50 = 0.407 nM
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| 5 |
IC50 = 2.449 nM
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CP0911503
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Methyl [(S)-1-((S)-2-{5-[(5-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-1H-imidazol-5-yl}biphenyl-2-yl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
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C44H52Cl2N8O6
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4
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| 1 |
IC50 = 0.03 nM
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| 2 |
IC50 = 0.072 nM
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| 3 |
IC50 = 0.129 nM
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| 4 |
IC50 = 1.311 nM
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CP0911501
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Methyl {(S)-1-[(S)-2-(5-{4-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-3-(4-methylpiperazin-1-yl)phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C46H56Cl2N10O6
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5
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| 1 |
IC50 = 0.034 nM
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| 2 |
IC50 = 0.143 nM
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| 3 |
IC50 = 0.473 nM
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| 4 |
IC50 = 3.1 nM
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| 5 |
IC50 > 10 nM
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CP0911506
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Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-1,1':4',1''-terphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C53H54Cl2N8O6
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3
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| 1 |
IC50 = 0.064 nM
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| 2 |
IC50 = 0.131 nM
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| 3 |
IC50 = 0.418 nM
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CP0911510
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Methyl {(S)-1-[(S)-2-(5-{3'-tert-butyl-6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]biphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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C51H58Cl2N8O6
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4
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| 1 |
IC50 = 0.093 nM
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| 2 |
IC50 = 0.104 nM
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| 3 |
IC50 = 0.107 nM
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| 4 |
IC50 = 1.069 nM
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