General Information of the Compound
Compound ID
CP0426216
Compound Name
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(morpholine-4-carbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]morpholine-4-carboxamide
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Structure
Formula
C52H54N8O6S2
Molecular Weight
951.188
Canonical SMILES
O=C(N[C@@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)N1CCOCC1)c1ccccc1)c1ccccc1)N1CCOCC1
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InChI
InChI=1S/C52H54N8O6S2/c61-49(45(39-9-3-1-4-10-39)55-51(63)57-25-29-65-30-26-57)59-23-7-13-41(59)47-53-33-43(67-47)37-19-15-35(16-20-37)36-17-21-38(22-18-36)44-34-54-48(68-44)42-14-8-24-60(42)50(62)46(40-11-5-2-6-12-40)56-52(64)58-27-31-66-32-28-58/h1-6,9-12,15-22,33-34,41-42,45-46H,7-8,13-14,23-32H2,(H,55,63)(H,56,64)/t41-,42-,45-,46+/m0/s1
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InChIKey
JAQSBZGLXYODOQ-KKWITKANSA-N
Physicochemical Property
logP
8.4938
Rotatable Bonds
11
Heavy Atom Count
68
Polar Areas
149.54
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
68

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155514620
ChEMBL ID
CHEMBL4440654
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 1.13 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
CC50 > 50000 nM
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