General Information of the Compound
Compound ID
CP0865366
Compound Name
methyl N-[(1S)-1-[(2S)-2-[5-[7-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-4,5,9,10-tetrahydropyren-2-yl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate
    Show/Hide
Structure
Formula
C44H54N8O6
Molecular Weight
790.966
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2cc3c4c(c2)CCc2cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]5)cc(c2-4)CC3)[nH]1)C(C)C
    Show/Hide
InChI
InChI=1S/C44H54N8O6/c1-23(2)37(49-43(55)57-5)41(53)51-15-7-9-33(51)39-45-21-31(47-39)29-17-25-11-13-27-19-30(20-28-14-12-26(18-29)35(25)36(27)28)32-22-46-40(48-32)34-10-8-16-52(34)42(54)38(24(3)4)50-44(56)58-6/h17-24,33-34,37-38H,7-16H2,1-6H3,(H,45,47)(H,46,48)(H,49,55)(H,50,56)/t33-,34-,37-,38-/m0/s1
    Show/Hide
InChIKey
MIZRANNEFVGTPV-JOJDORDVSA-N
Physicochemical Property
logP
6.4192
Rotatable Bonds
10
Heavy Atom Count
58
Polar Areas
174.64
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
58

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 67681768
ChEMBL ID
CHEMBL3914296
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 0.021 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.131 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.156 nM
   TI
   LI
   LO
   TS
4
EC50 = 13.3 nM
   TI
   LI
   LO
   TS