General Information of the Compound
Compound ID
CP0460692
Compound Name
methyl N-[(1S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]naphthalen-1-yl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methylpropyl]carbamate
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Structure
Formula
C42H51N9O6
Molecular Weight
777.927
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(cc2[nH]1)-c1cccc2cc(ccc12)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C(C)C
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InChI
InChI=1S/C42H51N9O6/c1-23(2)35(47-41(54)56-5)39(52)50-18-8-12-33(50)37-43-22-32(46-37)27-14-16-29-25(20-27)10-7-11-28(29)26-15-17-30-31(21-26)45-38(44-30)34-13-9-19-51(34)40(53)48-36(24(3)4)49-42(55)57-6/h7,10-11,14-17,20-24,33-36H,8-9,12-13,18-19H2,1-6H3,(H,43,46)(H,44,45)(H,47,54)(H,48,53)(H,49,55)/t33-,34-,35-,36-/m0/s1
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InChIKey
JTECZHBGIYIRBJ-ZYADHFCISA-N
Physicochemical Property
logP
7.0019
Rotatable Bonds
10
Heavy Atom Count
57
Polar Areas
186.67
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Complexity
57

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155515604
ChEMBL ID
CHEMBL4442126
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 > 3.7 nM
   TI
   LI
   LO
   TS
2
EC50 > 100 nM
   TI
   LI
   LO
   TS