General Information of the Compound
Compound ID
CP0865375
Compound Name
methyl N-[(2S)-1-[(2S)-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-6,8-diazapentacyclo[11.8.0.02,10.05,9.014,19]henicosa-1(13),2(10),3,5(9),7,11,14(19),15,17-nonaen-7-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C43H50N8O7
Molecular Weight
790.922
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)COc2c-3ccc3c2ccc2nc([C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c23)[nH]1)C(C)C
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InChI
InChI=1S/C43H50N8O7/c1-22(2)34(48-42(54)56-5)40(52)50-17-7-9-32(50)38-44-20-31(46-38)24-11-12-26-25(19-24)21-58-37-28(26)14-13-27-29(37)15-16-30-36(27)47-39(45-30)33-10-8-18-51(33)41(53)35(23(3)4)49-43(55)57-6/h11-16,19-20,22-23,32-35H,7-10,17-18,21H2,1-6H3,(H,44,46)(H,45,47)(H,48,54)(H,49,55)/t32-,33-,34-,35-/m0/s1
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InChIKey
OXGZSKDYWAHWDH-BBACVFHCSA-N
Physicochemical Property
logP
6.7538
Rotatable Bonds
9
Heavy Atom Count
58
Polar Areas
183.87
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
58

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67682530
ChEMBL ID
CHEMBL4453135
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  5
1
EC50 = 0.016 nM
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2
EC50 = 0.017 nM
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3
EC50 = 0.041 nM
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4
EC50 = 20.9 nM
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5
EC50 = 32.3 nM
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