General Information of the Compound
Compound ID
CP0931254
Compound Name
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
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Structure
Formula
C48H52N8O8
Molecular Weight
868.992
Canonical SMILES
COC[C@H]1C[C@@H](c2ncc(-c3ccc4c(c3)COc3cc5c(ccc6nc([C@@H]7CCCN7C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c65)cc3-4)[nH]2)N(C(=O)[C@H](NC(=O)OC)c2ccccc2)C1
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InChI
InChI=1S/C48H52N8O8/c1-26(2)40(53-47(59)62-4)45(57)55-17-9-12-37(55)44-50-35-16-14-29-20-34-32-15-13-30(19-31(32)25-64-39(34)21-33(29)42(35)52-44)36-22-49-43(51-36)38-18-27(24-61-3)23-56(38)46(58)41(54-48(60)63-5)28-10-7-6-8-11-28/h6-8,10-11,13-16,19-22,26-27,37-38,40-41H,9,12,17-18,23-25H2,1-5H3,(H,49,51)(H,50,52)(H,53,59)(H,54,60)/t27-,37-,38-,40-,41+/m0/s1
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InChIKey
VDZUVXBTHOADTK-LBJGZVHDSA-N
Physicochemical Property
logP
7.343
Rotatable Bonds
11
Heavy Atom Count
64
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
64

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67681739
ChEMBL ID
CHEMBL4467926
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.011 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.013 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.019 nM
   TI
   LI
   LO
   TS