General Information of the Compound
Compound ID
CP0901622
Compound Name
benzyl N-[4-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]amino]-4-oxo-butyl]carbamate
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Structure
Formula
C43H46N6O5
Molecular Weight
726.878
Canonical SMILES
CCCC(=O)Nc1ccc(-c2ccc(-c3c[nH]c([C@@H]4CCCN4C(=O)[C@H](NC(=O)CCCNC(=O)OCc4ccccc4)c4ccccc4)n3)cc2)cc1
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InChI
InChI=1S/C43H46N6O5/c1-2-11-38(50)46-35-24-22-32(23-25-35)31-18-20-33(21-19-31)36-28-45-41(47-36)37-16-10-27-49(37)42(52)40(34-14-7-4-8-15-34)48-39(51)17-9-26-44-43(53)54-29-30-12-5-3-6-13-30/h3-8,12-15,18-25,28,37,40H,2,9-11,16-17,26-27,29H2,1H3,(H,44,53)(H,45,47)(H,46,50)(H,48,51)/t37-,40+/m0/s1
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InChIKey
LOHFZNKALOTZPK-OMBCEYFDSA-N
Physicochemical Property
logP
7.7099
Rotatable Bonds
15
Heavy Atom Count
54
Polar Areas
145.52
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
54

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156015476
ChEMBL ID
CHEMBL4640942
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 0.15 nM
   TI
   LI
   LO
   TS
2
EC50 = 56 nM
   TI
   LI
   LO
   TS