General Information of the Compound
Compound ID
CP0937963
Compound Name
methyl N-[(1R)-2-oxo-1-phenyl-2-[(2S)-2-[4-(4-phenylphenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl]ethyl]carbamate
    Show/Hide
Structure
Formula
C29H28N4O3
Molecular Weight
480.568
Canonical SMILES
COC(=O)N[C@@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccccc3)cc2)c[nH]1)c1ccccc1
    Show/Hide
InChI
InChI=1S/C29H28N4O3/c1-36-29(35)32-26(23-11-6-3-7-12-23)28(34)33-18-8-13-25(33)27-30-19-24(31-27)22-16-14-21(15-17-22)20-9-4-2-5-10-20/h2-7,9-12,14-17,19,25-26H,8,13,18H2,1H3,(H,30,31)(H,32,35)/t25-,26+/m0/s1
    Show/Hide
InChIKey
UONXPPYPFQLQKS-IZZNHLLZSA-N
Physicochemical Property
logP
5.5045
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
87.32
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 156016664
ChEMBL ID
CHEMBL4642161
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 57 nM
   TI
   LI
   LO
   TS
2
EC50 = 2800 nM
   TI
   LI
   LO
   TS