General Information of the Compound
Compound ID
CP0944471
Compound Name
benzyl N-[2-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]phenyl]carbamate
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Structure
Formula
C46H44N6O5
Molecular Weight
760.895
Canonical SMILES
CCCC(=O)Nc1ccc(-c2ccc(-c3c[nH]c([C@@H]4CCCN4C(=O)[C@H](NC(=O)c4ccccc4NC(=O)OCc4ccccc4)c4ccccc4)n3)cc2)cc1
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InChI
InChI=1S/C46H44N6O5/c1-2-12-41(53)48-36-26-24-33(25-27-36)32-20-22-34(23-21-32)39-29-47-43(49-39)40-19-11-28-52(40)45(55)42(35-15-7-4-8-16-35)51-44(54)37-17-9-10-18-38(37)50-46(56)57-30-31-13-5-3-6-14-31/h3-10,13-18,20-27,29,40,42H,2,11-12,19,28,30H2,1H3,(H,47,49)(H,48,53)(H,50,56)(H,51,54)/t40-,42+/m0/s1
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InChIKey
ONDGRDWTDCJFPL-DUAROTRBSA-N
Physicochemical Property
logP
9.0658
Rotatable Bonds
13
Heavy Atom Count
57
Polar Areas
145.52
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
57

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156011924
ChEMBL ID
CHEMBL4638294
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 614 nM
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