General Information of the Compound
Compound ID
CP0869647
Compound Name
methyl N-[(1R)-2-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S)-1-(methoxycarbonylamino)-2-methyl-propyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamate
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Structure
Formula
C45H49N9O6
Molecular Weight
811.944
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@H](NC(=O)OC)c6ccccc6)[nH]5)ccc4c3)cc2[nH]1)C(C)C
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InChI
InChI=1S/C45H49N9O6/c1-26(2)39(52-45(58)60-4)51-43(56)54-21-9-13-37(54)41-47-33-19-18-31(24-34(33)48-41)29-14-15-30-23-32(17-16-28(30)22-29)35-25-46-40(49-35)36-12-8-20-53(36)42(55)38(50-44(57)59-3)27-10-6-5-7-11-27/h5-7,10-11,14-19,22-26,36-39H,8-9,12-13,20-21H2,1-4H3,(H,46,49)(H,47,48)(H,50,57)(H,51,56)(H,52,58)/t36-,37-,38+,39-/m0/s1
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InChIKey
OEVKBCXAOXQRTD-RUPCYPOASA-N
Physicochemical Property
logP
7.7186
Rotatable Bonds
10
Heavy Atom Count
60
Polar Areas
186.67
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155531370
ChEMBL ID
CHEMBL4465723
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.014 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.03 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.22 nM
   TI
   LI
   LO
   TS