General Information of the Compound
Compound ID
CP0949895
Compound Name
methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
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Structure
Formula
C49H54N8O8
Molecular Weight
883.019
Canonical SMILES
COC[C@H]1C[C@@H](c2ncc(-c3ccc4c(c3)COc3cc5c(ccc6nc([C@@H]7C[C@H](C)CN7C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c65)cc3-4)[nH]2)N(C(=O)[C@H](NC(=O)OC)c2ccccc2)C1
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InChI
InChI=1S/C49H54N8O8/c1-26(2)41(54-48(60)63-5)46(58)56-22-27(3)16-38(56)45-51-36-15-13-30-19-35-33-14-12-31(18-32(33)25-65-40(35)20-34(30)43(36)53-45)37-21-50-44(52-37)39-17-28(24-62-4)23-57(39)47(59)42(55-49(61)64-6)29-10-8-7-9-11-29/h7-15,18-21,26-28,38-39,41-42H,16-17,22-25H2,1-6H3,(H,50,52)(H,51,53)(H,54,60)(H,55,61)/t27-,28-,38-,39-,41-,42+/m0/s1
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InChIKey
BQFUFRJUGDYITB-CDIODLITSA-N
Physicochemical Property
logP
7.589
Rotatable Bonds
11
Heavy Atom Count
65
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
65

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 86688348
ChEMBL ID
CHEMBL4557789
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  5
1
EC50 = 0.011 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.013 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.014 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.015 nM
   TI
   LI
   LO
   TS
5
EC50 = 0.017 nM
   TI
   LI
   LO
   TS