General Information of the Compound
Compound ID
CP0421076
Compound Name
N-[(1S)-2-oxo-1-phenyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-phenyl-2-(thiophene-2-carbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]ethyl]thiophene-2-carboxamide
    Show/Hide
Structure
Formula
C52H44N6O4S4
Molecular Weight
945.23
Canonical SMILES
O=C(N[C@@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1cccs1)c1ccccc1)c1ccccc1)c1cccs1
    Show/Hide
InChI
InChI=1S/C52H44N6O4S4/c59-47(41-17-9-29-63-41)55-45(37-11-3-1-4-12-37)51(61)57-27-7-15-39(57)49-53-31-43(65-49)35-23-19-33(20-24-35)34-21-25-36(26-22-34)44-32-54-50(66-44)40-16-8-28-58(40)52(62)46(38-13-5-2-6-14-38)56-48(60)42-18-10-30-64-42/h1-6,9-14,17-26,29-32,39-40,45-46H,7-8,15-16,27-28H2,(H,55,59)(H,56,60)/t39-,40-,45-,46+/m0/s1
    Show/Hide
InChIKey
AGRYTHOOPDGAEC-PILDEOJGSA-N
Physicochemical Property
logP
11.3932
Rotatable Bonds
13
Heavy Atom Count
66
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
66

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 53247393
SID: 124363717
ChEMBL ID
CHEMBL4586142
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 109.8 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
CC50 > 50000 nM
   TI
   LI
   LO
   TS