General Information of the Compound
Compound ID
CP0911506
Compound Name
Methyl {(S)-1-[(S)-2-(5-{6-[(2-{(S)-1-[(R)-2-(methoxycarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)buta-1,3-diynyl]-1,1':4',1''-terphenyl-3-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methylpropyl}carbamate dihydrochloride
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Structure
Formula
C53H54Cl2N8O6
Molecular Weight
969.971
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(C#CC#Cc3cnc([C@@H]4CCCN4C(=O)[C@H](NC(=O)OC)c4ccccc4)[nH]3)c(-c3ccc(-c4ccccc4)cc3)c2)[nH]1)C(C)C.Cl.Cl
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InChI
InChI=1S/C53H52N8O6.2ClH/c1-34(2)46(58-52(64)66-3)50(62)60-29-14-22-45(60)49-55-33-43(57-49)40-28-27-37(42(31-40)38-25-23-36(24-26-38)35-15-7-5-8-16-35)17-11-12-20-41-32-54-48(56-41)44-21-13-30-61(44)51(63)47(59-53(65)67-4)39-18-9-6-10-19-39;;/h5-10,15-16,18-19,23-28,31-34,44-47H,13-14,21-22,29-30H2,1-4H3,(H,54,56)(H,55,57)(H,58,64)(H,59,65);2*1H/t44-,45-,46-,47+;;/m0../s1
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InChIKey
ZGLWNBTWHASRBV-JYIZQLJCSA-N
Physicochemical Property
logP
9.1855
Rotatable Bonds
11
Heavy Atom Count
69
Polar Areas
174.64
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
69

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 126647218
ChEMBL ID
CHEMBL4764688
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
IC50 = 0.064 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.131 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.418 nM
   TI
   LI
   LO
   TS