General Information of the Compound
Compound ID
CP0865365
Compound Name
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(triphenylene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
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Structure
Formula
C46H52N8O6
Molecular Weight
812.972
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c4ccc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]5)cc4c4ccccc4c3c2)[nH]1)C(C)C
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InChI
InChI=1S/C46H52N8O6/c1-25(2)39(51-45(57)59-5)43(55)53-19-9-13-37(53)41-47-23-35(49-41)27-15-17-31-32-18-16-28(22-34(32)30-12-8-7-11-29(30)33(31)21-27)36-24-48-42(50-36)38-14-10-20-54(38)44(56)40(26(3)4)52-46(58)60-6/h7-8,11-12,15-18,21-26,37-40H,9-10,13-14,19-20H2,1-6H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t37-,38-,39-,40-/m0/s1
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InChIKey
FNIDLYWHLYWABH-YKKXUYLKSA-N
Physicochemical Property
logP
8.0146
Rotatable Bonds
10
Heavy Atom Count
60
Polar Areas
174.64
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 88359300
ChEMBL ID
CHEMBL4550389
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.02 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.092 nM
   TI
   LI
   LO
   TS
3
EC50 = 6.79 nM
   TI
   LI
   LO
   TS