Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Methyl [(S)-1-((S)-2-{5-[4-(4'-tert-butyl-5-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}biphenyl-2-yl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
    Show/Hide
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(C#CC#Cc2ccc(-c3cnc([C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]3)cc2-c2ccc(C(C)(C)C)cc2)[nH]1)C(C)C.Cl.Cl.Cl.Cl
    Show/Hide
Compound Formula C48H62Cl4N8O6
Compound Structure
Protein Name
 Protein Info 
Nonstructural protein 5A
Protein Classification
Unclassified protein
Uniprot ID
Q5L478
Gene Name
NS5A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7
 Cell Line Info 
Homo sapiens (Human)  5
1
IC50 = 0.011 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.356 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.642 nM
   TI
   LI
   LO
   TS
4
IC50 = 1.286 nM
   TI
   LI
   LO
   TS
5
IC50 = 1.684 nM
   TI
   LI
   LO
   TS