General Information of the Compound
Compound ID
CP0865360
Compound Name
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(5,10-dihydrochromeno[5,4,3-cde]chromene-2,7-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
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Structure
Formula
C42H50N8O8
Molecular Weight
794.91
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2cc3c4c(c2)OCc2cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]5)cc(c2-4)OC3)[nH]1)C(C)C
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InChI
InChI=1S/C42H50N8O8/c1-21(2)35(47-41(53)55-5)39(51)49-11-7-9-29(49)37-43-17-27(45-37)23-13-25-19-58-32-16-24(14-26-20-57-31(15-23)33(25)34(26)32)28-18-44-38(46-28)30-10-8-12-50(30)40(52)36(22(3)4)48-42(54)56-6/h13-18,21-22,29-30,35-36H,7-12,19-20H2,1-6H3,(H,43,45)(H,44,46)(H,47,53)(H,48,54)/t29-,30-,35-,36-/m0/s1
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InChIKey
CZJLHTLISCSKPK-ACZARZSMSA-N
Physicochemical Property
logP
6.0068
Rotatable Bonds
10
Heavy Atom Count
58
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
58

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59610216
ChEMBL ID
CHEMBL4436929
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  8
1
EC50 = 0.016 nM
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2
EC50 = 0.022 nM
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3
EC50 = 0.029 nM
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4
EC50 = 0.056 nM
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5
EC50 = 1.16 nM
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6
EC50 = 1.77 nM
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7
EC50 = 5.9 nM
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8
EC50 = 8.81 nM
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