General Information of the Compound
Compound ID
CP0930993
Compound Name
MethylN-[(1R)-2-[(2S)-2-{5-[4-(4-{2-[(2S)-1-[(2R)-2-[(Methoxycarbonyl)amino]-2-phenylacetyl]pyrrolidin-2-yl]-1H-1Himidazol-5-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
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Structure
Formula
C46H46N8O6
Molecular Weight
806.924
Canonical SMILES
COC(=O)N[C@@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@H](NC(=O)OC)c5ccccc5)[nH]4)cc3)cc2)[nH]1)c1ccccc1
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InChI
InChI=1S/C46H46N8O6/c1-59-45(57)51-39(33-11-5-3-6-12-33)43(55)53-25-9-15-37(53)41-47-27-35(49-41)31-21-17-29(18-22-31)30-19-23-32(24-20-30)36-28-48-42(50-36)38-16-10-26-54(38)44(56)40(52-46(58)60-2)34-13-7-4-8-14-34/h3-8,11-14,17-24,27-28,37-40H,9-10,15-16,25-26H2,1-2H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t37-,38-,39+,40+/m0/s1
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InChIKey
XXYNKLCTNZTKRV-JPYDVTDNSA-N
Physicochemical Property
logP
7.6554
Rotatable Bonds
11
Heavy Atom Count
60
Polar Areas
174.64
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68054207
ChEMBL ID
CHEMBL3128176
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 0.014 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.098 nM
   TI
   LI
   LO
   TS