General Information of the Compound
Compound ID
CP0867642
Compound Name
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(dibenzo[f,h]quinoxaline-6,11-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
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Structure
Formula
C44H50N10O6
Molecular Weight
814.948
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c4ccc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]5)cc4c4nccnc4c3c2)[nH]1)C(C)C
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InChI
InChI=1S/C44H50N10O6/c1-23(2)35(51-43(57)59-5)41(55)53-17-7-9-33(53)39-47-21-31(49-39)25-11-13-27-28-14-12-26(20-30(28)38-37(29(27)19-25)45-15-16-46-38)32-22-48-40(50-32)34-10-8-18-54(34)42(56)36(24(3)4)52-44(58)60-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t33-,34-,35-,36-/m0/s1
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InChIKey
OQHGZYAVOVVZHV-ZYADHFCISA-N
Physicochemical Property
logP
6.8046
Rotatable Bonds
10
Heavy Atom Count
60
Polar Areas
200.42
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 88359426
ChEMBL ID
CHEMBL4469219
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.018 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.223 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.528 nM
   TI
   LI
   LO
   TS