General Information of the Compound
Compound ID
CP0941215
Compound Name
methyl N-[(2S)-1-[(2S)-2-[5-[6-[(2S,4S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-4-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C44H52N8O7
Molecular Weight
804.949
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6C[C@H](C)CN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c54)cc2-3)[nH]1)C(C)C
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InChI
InChI=1S/C44H52N8O7/c1-22(2)36(49-43(55)57-6)41(53)51-14-8-9-33(51)39-45-19-32(47-39)26-10-12-28-27(16-26)21-59-35-18-29-25(17-30(28)35)11-13-31-38(29)48-40(46-31)34-15-24(5)20-52(34)42(54)37(23(3)4)50-44(56)58-7/h10-13,16-19,22-24,33-34,36-37H,8-9,14-15,20-21H2,1-7H3,(H,45,47)(H,46,48)(H,49,55)(H,50,56)/t24-,33-,34-,36-,37-/m0/s1
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InChIKey
RYANBKAVEFUKLN-NZOYNQROSA-N
Physicochemical Property
logP
6.9998
Rotatable Bonds
9
Heavy Atom Count
59
Polar Areas
183.87
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
59

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89590784
ChEMBL ID
CHEMBL4450375
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 0.011 nM
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2
EC50 = 0.018 nM
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3
EC50 = 0.132 nM
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4
EC50 = 0.443 nM
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