General Information of the Compound
Compound ID
CP0865367
Compound Name
methyl N-[(1R)-2-[(2S)-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate
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Structure
Formula
C46H48N8O7
Molecular Weight
824.939
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc3c(c2)COc2cc4c(ccc5nc([C@@H]6CCCN6C(=O)[C@H](NC(=O)OC)c6ccccc6)[nH]c54)cc2-3)[nH]1)C(C)C
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InChI
InChI=1S/C46H48N8O7/c1-25(2)38(51-45(57)59-3)43(55)53-18-8-12-35(53)41-47-23-34(49-41)28-14-16-30-29(20-28)24-61-37-22-31-27(21-32(30)37)15-17-33-40(31)50-42(48-33)36-13-9-19-54(36)44(56)39(52-46(58)60-4)26-10-6-5-7-11-26/h5-7,10-11,14-17,20-23,25,35-36,38-39H,8-9,12-13,18-19,24H2,1-4H3,(H,47,49)(H,48,50)(H,51,57)(H,52,58)/t35-,36-,38-,39+/m0/s1
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InChIKey
UVDRNMFWRGJGIM-HXSJKTFTSA-N
Physicochemical Property
logP
7.4705
Rotatable Bonds
9
Heavy Atom Count
61
Polar Areas
183.87
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
61

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67682413
ChEMBL ID
CHEMBL4516340
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 0.012 nM
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2
EC50 = 0.021 nM
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3
EC50 = 0.022 nM
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4
EC50 = 0.134 nM
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