General Information of the Compound
Compound ID
CP0904046
Compound Name
methyl N-[(1S)-2-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S)-1-(methoxycarbonylamino)-2-methyl-propyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-tetrahydropyran-4-yl-ethyl]carbamate
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Structure
Formula
C44H53N9O7
Molecular Weight
819.964
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C6CCOCC6)[nH]5)ccc4c3)cc2[nH]1)C(C)C
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InChI
InChI=1S/C44H53N9O7/c1-25(2)38(51-44(57)59-4)50-42(55)53-18-6-8-36(53)40-46-32-14-13-30(23-33(32)47-40)28-9-10-29-22-31(12-11-27(29)21-28)34-24-45-39(48-34)35-7-5-17-52(35)41(54)37(49-43(56)58-3)26-15-19-60-20-16-26/h9-14,21-26,35-38H,5-8,15-20H2,1-4H3,(H,45,48)(H,46,47)(H,49,56)(H,50,55)(H,51,57)/t35-,36-,37-,38-/m0/s1
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InChIKey
KGQWUBRADCZADK-ZQWQDMLBSA-N
Physicochemical Property
logP
6.7725
Rotatable Bonds
10
Heavy Atom Count
60
Polar Areas
195.9
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
9
Complexity
60

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155531056
ChEMBL ID
CHEMBL4590699
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.03 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.08 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.89 nM
   TI
   LI
   LO
   TS