General Information of the Compound
Compound ID
CP0434314
Compound Name
N-[(1R)-1-cyclohexyl-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-cyclohexyl-2-(cyclopropanecarbonylamino)acetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]cyclopropanecarboxamide
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Structure
Formula
C50H60N6O4S2
Molecular Weight
873.202
Canonical SMILES
O=C(N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)C1CC1)C1CCCCC1)C1CC1
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InChI
InChI=1S/C50H60N6O4S2/c57-45(37-23-24-37)53-43(35-9-3-1-4-10-35)49(59)55-27-7-13-39(55)47-51-29-41(61-47)33-19-15-31(16-20-33)32-17-21-34(22-18-32)42-30-52-48(62-42)40-14-8-28-56(40)50(60)44(36-11-5-2-6-12-36)54-46(58)38-25-26-38/h15-22,29-30,35-40,43-44H,1-14,23-28H2,(H,53,57)(H,54,58)/t39-,40-,43+,44+/m0/s1
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InChIKey
OUFRFORUHGGTBA-XCIZVNRNSA-N
Physicochemical Property
logP
9.8778
Rotatable Bonds
13
Heavy Atom Count
62
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
62

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246311
SID: 124362616
ChEMBL ID
CHEMBL4546321
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 > 50000 nM
   TI
   LI
   LO
   TS