General Information of the Compound
Compound ID
CP0904638
Compound Name
N-[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]-7-phenyl-heptanamide
    Show/Hide
Structure
Formula
C44H49N5O3
Molecular Weight
695.908
Canonical SMILES
CCCC(=O)Nc1ccc(-c2ccc(-c3c[nH]c([C@@H]4CCCN4C(=O)[C@H](NC(=O)CCCCCCc4ccccc4)c4ccccc4)n3)cc2)cc1
    Show/Hide
InChI
InChI=1S/C44H49N5O3/c1-2-14-40(50)46-37-28-26-34(27-29-37)33-22-24-35(25-23-33)38-31-45-43(47-38)39-20-13-30-49(39)44(52)42(36-18-10-6-11-19-36)48-41(51)21-12-4-3-7-15-32-16-8-5-9-17-32/h5-6,8-11,16-19,22-29,31,39,42H,2-4,7,12-15,20-21,30H2,1H3,(H,45,47)(H,46,50)(H,48,51)/t39-,42+/m0/s1
    Show/Hide
InChIKey
BKXQUENDOYMIFO-KWLHKINFSA-N
Physicochemical Property
logP
9.1965
Rotatable Bonds
16
Heavy Atom Count
52
Polar Areas
107.19
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 156020197
ChEMBL ID
CHEMBL4648650
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 642 nM
   TI
   LI
   LO
   TS