General Information of the Compound
Compound ID
CP0563257
Compound Name
N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(cyclopentanecarbonylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]cyclopentanecarboxamide
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Structure
Formula
C54H56N6O4S2
Molecular Weight
917.214
Canonical SMILES
O=C(N[C@@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)C1CCCC1)c1ccccc1)c1ccccc1)C1CCCC1
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InChI
InChI=1S/C54H56N6O4S2/c61-49(41-17-7-8-18-41)57-47(39-13-3-1-4-14-39)53(63)59-31-11-21-43(59)51-55-33-45(65-51)37-27-23-35(24-28-37)36-25-29-38(30-26-36)46-34-56-52(66-46)44-22-12-32-60(44)54(64)48(40-15-5-2-6-16-40)58-50(62)42-19-9-10-20-42/h1-6,13-16,23-30,33-34,41-44,47-48H,7-12,17-22,31-32H2,(H,57,61)(H,58,62)/t43-,44-,47-,48+/m0/s1
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InChIKey
FKTIPQIDSHVMBO-ONFDFNSZSA-N
Physicochemical Property
logP
11.023
Rotatable Bonds
13
Heavy Atom Count
66
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
66

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246898
SID: 124363214
ChEMBL ID
CHEMBL4441414
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 1.1 nM
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