General Information of the Compound
Compound ID
CP0563256
Compound Name
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamate
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Structure
Formula
C38H44N6O6S2
Molecular Weight
744.94
Canonical SMILES
CC[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@H](CC)NC(=O)OC
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InChI
InChI=1S/C38H44N6O6S2/c1-5-27(41-37(47)49-3)35(45)43-19-7-9-29(43)33-39-21-31(51-33)25-15-11-23(12-16-25)24-13-17-26(18-14-24)32-22-40-34(52-32)30-10-8-20-44(30)36(46)28(6-2)42-38(48)50-4/h11-18,21-22,27-30H,5-10,19-20H2,1-4H3,(H,41,47)(H,42,48)/t27-,28-,29-,30-/m0/s1
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InChIKey
XAQCMBCTXLVELQ-KRCBVYEFSA-N
Physicochemical Property
logP
7.1968
Rotatable Bonds
11
Heavy Atom Count
52
Polar Areas
143.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
52

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246422
SID: 124362728
ChEMBL ID
CHEMBL4451620
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 56.6 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
CC50 > 50000 nM
   TI
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   TS