General Information of the Compound
Compound ID
CP0869643
Compound Name
methyl N-[(1S,2R)-2-hydroxy-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-hydroxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]propyl]carbamate
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Structure
Formula
C40H47N9O8
Molecular Weight
781.871
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)[C@@H](C)O)[nH]5)ccc4c3)cc2[nH]1)[C@@H](C)O
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InChI
InChI=1S/C40H47N9O8/c1-21(50)33(45-39(54)56-3)37(52)48-15-5-7-31(48)35-41-20-30(44-35)27-12-11-23-17-24(9-10-25(23)18-27)26-13-14-28-29(19-26)43-36(42-28)32-8-6-16-49(32)38(53)46-34(22(2)51)47-40(55)57-4/h9-14,17-22,31-34,50-51H,5-8,15-16H2,1-4H3,(H,41,44)(H,42,43)(H,45,54)(H,46,53)(H,47,55)/t21-,22-,31+,32+,33+,34+/m1/s1
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InChIKey
NSBKGUXMULPRIR-WYTQEFFASA-N
Physicochemical Property
logP
4.4515
Rotatable Bonds
10
Heavy Atom Count
57
Polar Areas
227.13
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
10
Complexity
57

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155521915
ChEMBL ID
CHEMBL4451714
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 0.19 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.43 nM
   TI
   LI
   LO
   TS