General Information of the Compound
Compound ID
CP0907326
Compound Name
methyl N-[(1S,2S)-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-2-methyl-butyl]carbamate
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Structure
Formula
C43H53N9O7
Molecular Weight
807.953
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)OC)NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)[nH]5)ccc4c3)cc2[nH]1
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InChI
InChI=1S/C43H53N9O7/c1-7-24(2)37(50-43(56)59-6)49-41(54)52-19-9-11-35(52)39-45-31-17-16-29(22-32(31)46-39)27-12-13-28-21-30(15-14-26(28)20-27)33-23-44-38(47-33)34-10-8-18-51(34)40(53)36(25(3)57-4)48-42(55)58-5/h12-17,20-25,34-37H,7-11,18-19H2,1-6H3,(H,44,47)(H,45,46)(H,48,55)(H,49,54)(H,50,56)/t24-,25+,34-,35-,36-,37-/m0/s1
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InChIKey
KWRKMWXGHVVDPW-BFVJKTKTSA-N
Physicochemical Property
logP
6.7709
Rotatable Bonds
12
Heavy Atom Count
59
Polar Areas
195.9
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
9
Complexity
59

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155532010
ChEMBL ID
CHEMBL4473534
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.015 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.07 nM
   TI
   LI
   LO
   TS
3
EC50 = 1.03 nM
   TI
   LI
   LO
   TS