General Information of the Compound
Compound ID
CP0549482
Compound Name
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-4-methylpentanoyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamate
    Show/Hide
Structure
Formula
C42H52N6O6S2
Molecular Weight
801.048
Canonical SMILES
COC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)OC
    Show/Hide
InChI
InChI=1S/C42H52N6O6S2/c1-25(2)21-31(45-41(51)53-5)39(49)47-19-7-9-33(47)37-43-23-35(55-37)29-15-11-27(12-16-29)28-13-17-30(18-14-28)36-24-44-38(56-36)34-10-8-20-48(34)40(50)32(22-26(3)4)46-42(52)54-6/h11-18,23-26,31-34H,7-10,19-22H2,1-6H3,(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1
    Show/Hide
InChIKey
ZIZMZFBMMPUAJD-CUPIEXAXSA-N
Physicochemical Property
logP
8.469
Rotatable Bonds
13
Heavy Atom Count
56
Polar Areas
143.06
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
56

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 53246541
SID: 124362847
ChEMBL ID
CHEMBL4585945
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 179 nM
   TI
   LI
   LO
   TS