General Information of the Compound
Compound ID
CP0561767
Compound Name
2-methyl-N-[(1S)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(2-methylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]propanamide
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Structure
Formula
C50H52N6O4S2
Molecular Weight
865.138
Canonical SMILES
CC(C)C(=O)N[C@@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)C(C)C)c1ccccc1)c1ccccc1
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InChI
InChI=1S/C50H52N6O4S2/c1-31(2)45(57)53-43(37-13-7-5-8-14-37)49(59)55-27-11-17-39(55)47-51-29-41(61-47)35-23-19-33(20-24-35)34-21-25-36(26-22-34)42-30-52-48(62-42)40-18-12-28-56(40)50(60)44(54-46(58)32(3)4)38-15-9-6-10-16-38/h5-10,13-16,19-26,29-32,39-40,43-44H,11-12,17-18,27-28H2,1-4H3,(H,53,57)(H,54,58)/t39-,40-,43-,44+/m0/s1
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InChIKey
HWRNBLKSZLPZJX-KOSLULIRSA-N
Physicochemical Property
logP
9.9546
Rotatable Bonds
13
Heavy Atom Count
62
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
62

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 68318420
ChEMBL ID
CHEMBL4582491
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 0.31 nM
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