General Information of the Compound
Compound ID
CP0907324
Compound Name
methyl N-[(S)-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-2-tetrahydropyran-4-yl-acetyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]-tetrahydropyran-4-yl-methyl]carbamate
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Structure
Formula
C46H55N9O8
Molecular Weight
862.001
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C6CCOCC6)[nH]5)ccc4c3)cc2[nH]1)C1CCOCC1
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InChI
InChI=1S/C46H55N9O8/c1-60-45(58)51-39(27-13-19-62-20-14-27)43(56)54-17-3-5-37(54)41-47-26-36(50-41)33-10-9-29-23-30(7-8-31(29)24-33)32-11-12-34-35(25-32)49-42(48-34)38-6-4-18-55(38)44(57)52-40(53-46(59)61-2)28-15-21-63-22-16-28/h7-12,23-28,37-40H,3-6,13-22H2,1-2H3,(H,47,50)(H,48,49)(H,51,58)(H,52,57)(H,53,59)/t37-,38-,39-,40-/m0/s1
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InChIKey
UGPGGLRZHVFWGS-YKKXUYLKSA-N
Physicochemical Property
logP
6.5431
Rotatable Bonds
10
Heavy Atom Count
63
Polar Areas
205.13
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
10
Complexity
63

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155559011
ChEMBL ID
CHEMBL4562653
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.113 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.13 nM
   TI
   LI
   LO
   TS
3
EC50 = 1.1 nM
   TI
   LI
   LO
   TS