General Information of the Compound
Compound ID
CP0550941
Compound Name
N-[(1R)-2-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2R)-2-(2,2-dimethylpropanoylamino)-2-phenylacetyl]pyrrolidin-2-yl]-1,3-thiazol-5-yl]phenyl]phenyl]-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]-2,2-dimethylpropanamide
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Structure
Formula
C52H56N6O4S2
Molecular Weight
893.192
Canonical SMILES
CC(C)(C)C(=O)N[C@@H](C(=O)N1CCC[C@H]1c1ncc(s1)-c1ccc(cc1)-c1ccc(cc1)-c1cnc(s1)[C@@H]1CCCN1C(=O)[C@H](NC(=O)C(C)(C)C)c1ccccc1)c1ccccc1
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InChI
InChI=1S/C52H56N6O4S2/c1-51(2,3)49(61)55-43(37-15-9-7-10-16-37)47(59)57-29-13-19-39(57)45-53-31-41(63-45)35-25-21-33(22-26-35)34-23-27-36(28-24-34)42-32-54-46(64-42)40-20-14-30-58(40)48(60)44(38-17-11-8-12-18-38)56-50(62)52(4,5)6/h7-12,15-18,21-28,31-32,39-40,43-44H,13-14,19-20,29-30H2,1-6H3,(H,55,61)(H,56,62)/t39-,40-,43+,44+/m0/s1
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InChIKey
MWKRBTDTUCSFTQ-XCIZVNRNSA-N
Physicochemical Property
logP
10.7348
Rotatable Bonds
11
Heavy Atom Count
64
Polar Areas
124.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
64

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53246653
SID: 124362961
ChEMBL ID
CHEMBL4536669
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 1.35 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
CC50 > 50000 nM
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