General Information of the Compound
Compound ID
CP0869649
Compound Name
methyl N-[(1S,2R)-2-methoxy-1-[[(2S)-2-[6-[6-[2-[(2S)-1-[(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-2-naphthyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]amino]propyl]carbamate
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Structure
Formula
C42H51N9O8
Molecular Weight
809.925
Canonical SMILES
COC(=O)N[C@H](NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)[nH]5)ccc4c3)cc2[nH]1)[C@@H](C)OC
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InChI
InChI=1S/C42H51N9O8/c1-23(56-3)35(47-41(54)58-5)39(52)50-17-7-9-33(50)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-51(34)40(53)48-36(24(2)57-4)49-42(55)59-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,43,46)(H,44,45)(H,47,54)(H,48,53)(H,49,55)/t23-,24-,33+,34+,35+,36+/m1/s1
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InChIKey
OENBJFIBLNPMOE-OYDNEJTASA-N
Physicochemical Property
logP
5.7597
Rotatable Bonds
12
Heavy Atom Count
59
Polar Areas
205.13
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
10
Complexity
59

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155554271
ChEMBL ID
CHEMBL4578947
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.047 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.13 nM
   TI
   LI
   LO
   TS
3
EC50 = 1.5 nM
   TI
   LI
   LO
   TS