General Information of the Compound
Compound ID
CP0869648
Compound Name
methyl N-[(1S,2S)-1-[(2S)-2-[5-[6-[2-[(2S)-1-[[(1S,2S)-1-(methoxycarbonylamino)-2-methyl-butyl]carbamoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]-2-naphthyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-butyl]carbamate
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Structure
Formula
C44H55N9O6
Molecular Weight
805.981
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)OC)NC(=O)N1CCC[C@H]1c1nc2ccc(-c3ccc4cc(-c5cnc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)[C@@H](C)CC)[nH]5)ccc4c3)cc2[nH]1
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InChI
InChI=1S/C44H55N9O6/c1-7-25(3)37(49-43(56)58-5)41(54)52-19-9-11-35(52)39-45-24-34(48-39)31-16-15-27-21-28(13-14-29(27)22-31)30-17-18-32-33(23-30)47-40(46-32)36-12-10-20-53(36)42(55)50-38(26(4)8-2)51-44(57)59-6/h13-18,21-26,35-38H,7-12,19-20H2,1-6H3,(H,45,48)(H,46,47)(H,49,56)(H,50,55)(H,51,57)/t25-,26-,35-,36-,37-,38-/m0/s1
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InChIKey
ZFSLWZOHYKVMLI-WQIINBNLSA-N
Physicochemical Property
logP
7.7821
Rotatable Bonds
12
Heavy Atom Count
59
Polar Areas
186.67
Hydrogen Bond Donor Count
5
Hydrogen Bond Acceptor Count
8
Complexity
59

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155518644
ChEMBL ID
CHEMBL4446538
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  3
1
EC50 = 0.015 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.11 nM
   TI
   LI
   LO
   TS
3
EC50 = 2.3 nM
   TI
   LI
   LO
   TS