General Information of the Compound
Compound ID
CP0911507
Compound Name
Methyl [(S)-1-((S)-2-{5-[4-(5-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-yl}-[1,1';3',1'']terphenyl-2-yl)buta-1,3-diynyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methylpropyl]carbamate dihydrochloride
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Structure
Formula
C50H56Cl2N8O6
Molecular Weight
935.954
Canonical SMILES
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(C#CC#Cc2ccc(-c3cnc([C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]3)cc2-c2cccc(-c3ccccc3)c2)[nH]1)C(C)C.Cl.Cl
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InChI
InChI=1S/C50H54N8O6.2ClH/c1-31(2)43(55-49(61)63-5)47(59)57-25-13-21-41(57)45-51-29-38(53-45)20-11-10-17-34-23-24-37(28-39(34)36-19-12-18-35(27-36)33-15-8-7-9-16-33)40-30-52-46(54-40)42-22-14-26-58(42)48(60)44(32(3)4)56-50(62)64-6;;/h7-9,12,15-16,18-19,23-24,27-32,41-44H,13-14,21-22,25-26H2,1-6H3,(H,51,53)(H,52,54)(H,55,61)(H,56,62);2*1H/t41-,42-,43-,44-;;/m0../s1
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InChIKey
CUSIGCMDCJYENH-PLGVYSAESA-N
Physicochemical Property
logP
8.4688
Rotatable Bonds
11
Heavy Atom Count
66
Polar Areas
174.64
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
66

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 126647044
ChEMBL ID
CHEMBL4747100
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  5
1
IC50 = 0.0192 nM
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2
IC50 = 0.449 nM
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3
IC50 = 0.47 nM
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4
IC50 = 0.763 nM
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5
IC50 = 2.785 nM
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