General Information of the Compound
Compound ID
CP0912261
Compound Name
methyl N-[(2S)-1-[(2S,4S)-4-ethoxy-2-[17-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
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Structure
Formula
C45H54N8O8
Molecular Weight
834.975
Canonical SMILES
CCO[C@H]1C[C@@H](c2nc3ccc4cc5c(cc4c3[nH]2)OCc2cc(-c3cnc([C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]3)ccc2-5)N(C(=O)[C@@H](NC(=O)OC)C(C)C)C1
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InChI
InChI=1S/C45H54N8O8/c1-8-60-28-18-35(53(21-28)43(55)38(24(4)5)51-45(57)59-7)41-47-32-14-12-25-17-31-29-13-11-26(16-27(29)22-61-36(31)19-30(25)39(32)49-41)33-20-46-40(48-33)34-10-9-15-52(34)42(54)37(23(2)3)50-44(56)58-6/h11-14,16-17,19-20,23-24,28,34-35,37-38H,8-10,15,18,21-22H2,1-7H3,(H,46,48)(H,47,49)(H,50,56)(H,51,57)/t28-,34-,35-,37-,38-/m0/s1
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InChIKey
YTWJMIVKVBIOJL-OZAMDKPCSA-N
Physicochemical Property
logP
6.7688
Rotatable Bonds
11
Heavy Atom Count
61
Polar Areas
193.1
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
61

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67682290
ChEMBL ID
CHEMBL4542363
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  4
1
EC50 = 0.015 nM
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   TS
2
EC50 = 0.018 nM
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   TS
3
EC50 = 0.265 nM
   TI
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   LO
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4
EC50 = 0.378 nM
   TI
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   LO
   TS