General Information of the Compound
Compound ID
CP0867226
Compound Name
methyl N-[(3R)-1-[[(1R)-2-[(2S)-2-[4-[4-[4-(butanoylamino)phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl]carbamoyl]pyrrolidin-3-yl]carbamate
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Structure
Formula
C38H43N7O5
Molecular Weight
677.806
Canonical SMILES
CCCC(=O)Nc1ccc(-c2ccc(-c3c[nH]c([C@@H]4CCCN4C(=O)[C@H](NC(=O)N4CC[C@@H](NC(=O)OC)C4)c4ccccc4)n3)cc2)cc1
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InChI
InChI=1S/C38H43N7O5/c1-3-8-33(46)40-29-18-16-26(17-19-29)25-12-14-27(15-13-25)31-23-39-35(42-31)32-11-7-21-45(32)36(47)34(28-9-5-4-6-10-28)43-37(48)44-22-20-30(24-44)41-38(49)50-2/h4-6,9-10,12-19,23,30,32,34H,3,7-8,11,20-22,24H2,1-2H3,(H,39,42)(H,40,46)(H,41,49)(H,43,48)/t30-,32+,34-/m1/s1
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InChIKey
ALCPNYAJBBAPME-BBLOSTOYSA-N
Physicochemical Property
logP
6.027
Rotatable Bonds
10
Heavy Atom Count
50
Polar Areas
148.76
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
50

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156015381
ChEMBL ID
CHEMBL4640916
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00149, Nonstructural protein 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  2
1
EC50 = 0.043 nM
   TI
   LI
   LO
   TS
2
EC50 = 353 nM
   TI
   LI
   LO
   TS